{"id":"W2216093506","doi":"10.1158/1538-7445.am2015-ct329","title":"Abstract CT329: Phase I study of the PI3Kβ/δ inhibitor AZD8186 in patients with advanced castration resistant prostate cancer, triple negative breast cancer, squamous non-small cell lung cancer or PTEN deficient solid tumors: update from dose-finding","year":2015,"lang":"en","type":"article","venue":"Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; PTEN; Prostate cancer; Cancer; Breast cancer; PI3K/AKT/mTOR pathway; Tolerability; Internal medicine; Triple-negative breast cancer; Oncology; Adverse effect; Apoptosis; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001241149,0.00112141,0.001484727,0.0003836224,0.0002906551,0.0008524335,0.0009664647,0.0008516017,0.00432201],"category_scores_gemma":[0.0007955407,0.0003462194,0.0008528885,0.0006836744,0.0005297847,0.0005906048,0.000285902,0.002531762,0.001130462],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006624407,"about_ca_system_score_gemma":0.001405006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008871555,"about_ca_topic_score_gemma":0.002862853,"domain_scores_codex":[0.9997093,0.0001553825,0.00002233628,0.00003675137,0.00004221686,0.00003400207],"domain_scores_gemma":[0.999556,0.00007661142,0.0001047317,0.00003593953,0.00005278976,0.0001739478],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3596534,0.01734336,0.01262827,0.006202426,0.00230424,0.0008617027,0.0005748395,0.005520491,0.1634332,0.001484629,0.02508535,0.4049081],"study_design_scores_gemma":[0.5432315,0.3713871,0.03233896,0.0005109169,0.001329863,0.001994235,0.0001057679,0.002174507,0.0136749,0.0005723985,0.03258479,0.00009509707],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9446526,0.03026671,0.001912017,0.002300042,0.0003448403,0.004047633,0.005626685,0.0004906018,0.01035893],"genre_scores_gemma":[0.9491948,0.02128448,0.003974382,0.002630466,0.0003281886,0.003072159,0.009415342,0.0001058207,0.009994311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00432201,"threshold_uncertainty_score":0.0144586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03604909238887559,"score_gpt":0.3649542694304583,"score_spread":0.3289051770415827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}