{"id":"W2219126548","doi":"10.1038/ncb3259","title":"The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice","year":2015,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôtel-Dieu de Québec; Université Laval; Centre hospitalier universitaire de Québec; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"DNA ligase; Ubiquitin ligase; DNA repair; Homologous recombination; DNA damage; Cell biology; DNA; Biology; Non-homologous end joining; Ubiquitin; DNA repair protein XRCC4; Molecular biology; Genetics; Nucleotide excision repair; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003728086,0.0003627099,0.0003748562,0.0003001845,0.0003803486,0.001114851,0.0006197607,0.0004465047,0.005235603],"category_scores_gemma":[0.0005851124,0.0003554013,0.0002841224,0.0001726038,0.0004528126,0.0009026324,0.0007105966,0.0009714785,0.001438666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001296794,"about_ca_system_score_gemma":0.0004553083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001088888,"about_ca_topic_score_gemma":0.002240334,"domain_scores_codex":[0.9995545,0.000036076,0.00002543285,0.0001451718,0.0001470465,0.00009186458],"domain_scores_gemma":[0.9996349,0.00005214906,0.0001045111,0.00004872639,0.00006111466,0.00009857176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001741652,0.00002426685,0.0007085282,0.00001740644,0.000004933472,0.00004164569,0.00001356257,0.000141684,0.9946373,0.0008659979,0.000142482,0.003227878],"study_design_scores_gemma":[0.00001798141,0.00005569833,0.003324713,0.000003481511,0.000003318673,0.0000768815,0.00003505848,0.002166547,0.9924341,0.000252307,0.001621384,0.000008410601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984696,0.001382973,0.008741719,0.0003293859,0.00008446229,0.00001772294,0.0002670477,0.0004037202,0.004076868],"genre_scores_gemma":[0.9942468,0.0002031476,0.001946495,0.00005024834,0.000008540307,0.00001081433,0.0001918942,0.0001002627,0.003241909],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005235603,"threshold_uncertainty_score":0.01751488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00670996978114591,"score_gpt":0.2470806575018316,"score_spread":0.2403706877206857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}