{"id":"W2219126548","doi":"10.1038/ncb3259","title":"The RNF138 E3 ligase displaces Ku to promote DNA end resection and regulate DNA repair pathway choice","year":2015,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":147,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôtel-Dieu de Québec; Université Laval; Centre hospitalier universitaire de Québec; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"DNA ligase; Ubiquitin ligase; DNA repair; Homologous recombination; DNA damage; Cell biology; DNA; Biology; Non-homologous end joining; Ubiquitin; DNA repair protein XRCC4; Molecular biology; Genetics; Nucleotide excision repair; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007133319,0.0002362631,0.0001816029,0.00005089511,0.0001723684,0.00003307065,0.0002752047,0.0008184982,0.000005512794],"category_scores_gemma":[0.0005400366,0.0001644701,0.00008902724,0.0001362279,0.000131183,0.000005700791,0.0003013337,0.0003514979,0.00001737954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003104528,"about_ca_system_score_gemma":0.00008624611,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002284989,"about_ca_topic_score_gemma":0.0002589706,"domain_scores_codex":[0.998357,0.0002161236,0.0002187984,0.0006746444,0.000121795,0.0004116619],"domain_scores_gemma":[0.9988345,0.00004934021,0.0001083921,0.0006284528,0.0001520196,0.0002273187],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002953958,0.00003302917,0.0001998338,0.00001402835,0.00003474779,0.000005767225,0.00005848076,0.000004163131,0.9904143,0.0002808118,0.005480827,0.003178602],"study_design_scores_gemma":[0.0003381834,0.0007624211,0.0002119149,0.000006517082,0.00001068381,0.00001950233,0.00003470695,0.00004070637,0.6297197,0.0003757745,0.3683334,0.0001465125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912282,0.004048095,0.00003950638,0.0007883189,0.0008168463,0.0004389439,0.00002712472,0.00007003632,0.002542905],"genre_scores_gemma":[0.993596,0.0001621313,0.0006393337,0.0005887483,0.0005349694,0.00004783304,0.0001154086,0.0000318082,0.004283781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3628526,"threshold_uncertainty_score":0.6706897,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00670996978114591,"score_gpt":0.2470806575018316,"score_spread":0.2403706877206857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}