{"id":"W2219488898","doi":"10.1200/jco.2012.30.15_suppl.lba671","title":"Open-label phase III randomized controlled trial comparing taxane-based chemotherapy (Tax) with lapatinib (L) or trastuzumab (T) as first-line therapy for women with HER2+ metastatic breast cancer: Interim analysis (IA) of NCIC CTG MA.31/GSK EGF 108919.","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Juravinski Cancer Centre; Sunnybrook Health Science Centre; BC Cancer Agency; Interior Health; Ottawa Hospital; Hamilton Health Sciences; University of Toronto","funders":"","keywords":"Medicine; Lapatinib; Trastuzumab; Taxane; Pertuzumab; Oncology; Internal medicine; Metastatic breast cancer; Interim analysis; Breast cancer; Interim; Chemotherapy; Clinical trial; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.007802627,0.0004713404,0.01155704,0.00039839,0.00009600545,0.00002868537,0.0004225338,0.0002431767,0.002797169],"category_scores_gemma":[0.0006000467,0.0002389354,0.001031571,0.0005651372,0.0005272892,0.0002245381,0.00003377597,0.0006508487,0.000001723449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005679249,"about_ca_system_score_gemma":0.004234643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002906736,"about_ca_topic_score_gemma":0.0005605253,"domain_scores_codex":[0.9930134,0.001275507,0.004218487,0.0003650583,0.0005175931,0.0006099977],"domain_scores_gemma":[0.9831392,0.008726741,0.006341978,0.0002936758,0.0008214707,0.0006768903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8905068,0.04000165,0.001997892,0.00007456607,0.03872723,0.00009661402,0.0005549273,0.0001497304,0.0002527364,0.000006657506,0.0004547761,0.02717644],"study_design_scores_gemma":[0.8526409,0.1264787,0.0005807919,0.0001394211,0.01472851,0.0001674388,0.0002029993,0.001478383,0.0003419143,0.00001938273,0.003000435,0.0002210595],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820544,0.0007002311,0.002573482,0.005142067,0.0007211114,0.008425652,0.00006130563,0.00001346737,0.0003083396],"genre_scores_gemma":[0.9879094,0.001182019,0.004144889,0.002528995,0.001169765,0.002168712,0.00002446388,0.0000567362,0.0008149933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08647706,"threshold_uncertainty_score":0.9981144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1781133608658888,"score_gpt":0.5349206746260675,"score_spread":0.3568073137601787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}