{"id":"W2219488898","doi":"10.1200/jco.2012.30.15_suppl.lba671","title":"Open-label phase III randomized controlled trial comparing taxane-based chemotherapy (Tax) with lapatinib (L) or trastuzumab (T) as first-line therapy for women with HER2+ metastatic breast cancer: Interim analysis (IA) of NCIC CTG MA.31/GSK EGF 108919.","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; Juravinski Cancer Centre; Sunnybrook Health Science Centre; BC Cancer Agency; Interior Health; Ottawa Hospital; Hamilton Health Sciences; University of Toronto","funders":"","keywords":"Medicine; Lapatinib; Trastuzumab; Taxane; Pertuzumab; Oncology; Internal medicine; Metastatic breast cancer; Interim analysis; Breast cancer; Interim; Chemotherapy; Clinical trial; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00216648,0.002045096,0.003663832,0.0003860776,0.0005957014,0.001339344,0.001244346,0.002043519,0.01618412],"category_scores_gemma":[0.002907828,0.0008077218,0.0017742,0.0005778422,0.001271966,0.001895413,0.0005268842,0.004732529,0.002576055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001047508,"about_ca_system_score_gemma":0.001711559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001507942,"about_ca_topic_score_gemma":0.00488161,"domain_scores_codex":[0.9993105,0.0003649641,0.0000433354,0.0001384203,0.00005022605,0.00009250733],"domain_scores_gemma":[0.9983891,0.0005146834,0.0003543781,0.0001404471,0.0001239577,0.0004772678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9827924,0.005628428,0.0001553898,0.0006698422,0.001121199,0.00002268656,0.00002669732,0.0001838901,0.0007339195,0.0001277635,0.001727007,0.006810765],"study_design_scores_gemma":[0.9838952,0.0147555,0.000318834,0.00002111906,0.0002218352,0.00001016796,0.00001122779,0.0001479027,0.00005792516,0.0001056568,0.0004487169,0.000005933595],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.918995,0.01894645,0.003366643,0.004453047,0.005853097,0.02529566,0.00956508,0.0007338984,0.0127912],"genre_scores_gemma":[0.9344909,0.008730716,0.005821932,0.005945675,0.00185389,0.02456835,0.005888462,0.0001151562,0.01258492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01618412,"threshold_uncertainty_score":0.05414128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1781133608658888,"score_gpt":0.5349206746260675,"score_spread":0.3568073137601787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}