{"id":"W2219863195","doi":"10.1002/cbic.201500644","title":"Use of Methylmalonyl‐CoA Epimerase in Enhancing Crotonase Stereoselectivity","year":2015,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Wellcome Trust","keywords":"Stereoselectivity; Biocatalysis; Chemistry; Pyruvate carboxylase; Reductase; Enzyme; Stereochemistry; Biochemistry; Catalysis; Reaction mechanism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004169629,0.0001494801,0.0003814364,0.0001122677,0.00001501089,0.0000119145,0.00007014483,0.0001214892,0.00006026799],"category_scores_gemma":[0.001270928,0.0001214734,0.00007909828,0.0003577513,0.00006702801,0.000120599,0.00006044703,0.000204316,0.00001651598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009328128,"about_ca_system_score_gemma":0.000150246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003467097,"about_ca_topic_score_gemma":0.00006270449,"domain_scores_codex":[0.9989571,0.00004148202,0.0002947437,0.000303187,0.000170759,0.0002327423],"domain_scores_gemma":[0.9991471,0.00008030557,0.00009549606,0.0003259167,0.0001899029,0.0001613111],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000298335,0.0002455322,0.002010533,0.0001175437,0.00002602,0.00002530135,0.0002090156,4.624217e-7,0.9914481,0.00001112845,0.001726429,0.00388162],"study_design_scores_gemma":[0.000740604,0.0001059189,0.001632334,0.0001245325,0.0000362049,0.00002295187,0.00005780446,0.00001698842,0.9943581,0.00002262382,0.002750239,0.0001316935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979857,0.0004863862,0.00001424166,0.0006445349,0.00007610692,0.0003452033,0.000008125166,0.00002775319,0.0004120008],"genre_scores_gemma":[0.9964927,0.00001652506,0.002091786,0.0002526175,0.0001005239,0.000002114929,0.00001337368,0.00001700514,0.001013291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003749926,"threshold_uncertainty_score":0.4953542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07874504486931252,"score_gpt":0.2938531372246605,"score_spread":0.215108092355348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}