{"id":"W2219920450","doi":"10.2967/jnumed.115.164848","title":"<sup>18</sup>F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease","year":2015,"lang":"en","type":"article","venue":"Journal of Nuclear Medicine","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":329,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"","keywords":"White matter; Human brain; Pathology; Pharmacokinetics; Medicine; Pet imaging; Tau pathology; Nuclear medicine; Positron emission tomography; Chemistry; Alzheimer's disease; Pharmacology; Disease; Magnetic resonance imaging; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008200106,0.0002536851,0.0007336585,0.0004946037,0.00005855083,0.00001543754,0.0001701208,0.00005014892,0.0002221772],"category_scores_gemma":[0.0009774363,0.0001793307,0.0002276272,0.0002567519,0.0002592801,0.0002437959,0.0000581503,0.000381468,0.00002869082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001437099,"about_ca_system_score_gemma":0.0005059451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000186879,"about_ca_topic_score_gemma":6.502731e-7,"domain_scores_codex":[0.9976237,0.0001083019,0.0006853206,0.0002774108,0.0007878037,0.0005174407],"domain_scores_gemma":[0.99718,0.000183735,0.0002703424,0.0003179524,0.0004822297,0.001565717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.05405303,0.006935026,0.2745479,0.0005659352,0.01428953,0.126301,0.004832363,0.0006388777,0.003931134,0.0006822551,0.4828903,0.03033268],"study_design_scores_gemma":[0.1700952,0.01674319,0.4618718,0.004016452,0.01677161,0.04889583,0.007378321,0.0568101,0.00009081129,0.002551021,0.213356,0.001419656],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8705706,0.06784601,0.0002286363,0.05678069,0.0006081615,0.001571484,0.00006566714,0.00006407966,0.002264647],"genre_scores_gemma":[0.9937493,0.0004476766,0.001639044,0.002763821,0.001252683,0.000008861145,0.00002378277,0.00008827192,0.00002659003],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2695343,"threshold_uncertainty_score":0.7312894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07233559243809977,"score_gpt":0.3537291876054788,"score_spread":0.2813935951673791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}