{"id":"W2220510462","doi":"10.1074/jbc.m115.664805","title":"Structural Characterization of Interaction between Human Ubiquitin-specific Protease 7 and Immediate-Early Protein ICP0 of Herpes Simplex Virus-1","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Lytic cycle; Deubiquitinating enzyme; Herpes simplex virus; Ubiquitin; Protease; Virus; Biology; Ubiquitin ligase; Virology; Cell biology; Chemistry; Molecular biology; Enzyme; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001378878,0.0002975588,0.0002305392,0.0001921678,0.0002215336,0.0001643369,0.000512212,0.0002601666,0.0006467236],"category_scores_gemma":[0.0003374941,0.0001268261,0.0002925188,0.0001658437,0.000177581,0.0002311687,0.0001595631,0.0004194801,0.0002036274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004998106,"about_ca_system_score_gemma":0.0002113265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00154102,"about_ca_topic_score_gemma":0.001022828,"domain_scores_codex":[0.9998853,0.00001854498,0.000005247598,0.00001973163,0.00004549757,0.00002562736],"domain_scores_gemma":[0.9998385,0.00004152651,0.0000387738,0.000009769047,0.00003333965,0.00003810727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002794167,0.00009274461,0.001133624,0.00009239052,0.00003474912,0.0002766636,0.00006812911,0.0007062319,0.9950283,0.0002791762,0.0001471829,0.001861385],"study_design_scores_gemma":[0.00003124175,0.0004099093,0.01926257,0.00002107553,0.00007941612,0.0006401547,0.0001370864,0.0133489,0.9606568,0.0002232175,0.005162327,0.00002737182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962803,0.001099752,0.001289512,0.00006345854,0.00001528687,0.00001071707,0.000220065,0.00001580788,0.001005173],"genre_scores_gemma":[0.9952845,0.0006648838,0.001761791,0.00006838929,0.0000111001,0.00001329227,0.001422344,0.00001247204,0.0007611917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00154102,"threshold_uncertainty_score":0.003626406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05156858457067835,"score_gpt":0.2827034255970556,"score_spread":0.2311348410263772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}