{"id":"W2220568998","doi":"10.1128/jvi.02353-15","title":"Population-Level Immune-Mediated Adaptation in HIV-1 Polymerase during the North American Epidemic","year":2015,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; University of British Columbia; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Cancer Institute; U.S. Department of Health and Human Services; Government of Canada; National Institutes of Health; Michael Smith Health Research BC; Frederick National Laboratory for Cancer Research","keywords":"Biology; Human leukocyte antigen; Population; Allele; Genetics; Genotype; Virology; Immunology; Demography; Antigen; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004466682,0.00008508062,0.0001185756,0.0004613929,0.0003826084,0.0004970405,0.0003082837,0.0002612777,0.0009654744],"category_scores_gemma":[0.001071392,0.00009025319,0.00009143705,0.0007429435,0.0003993549,0.0003815088,0.0003672519,0.0003350223,0.00008237147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006622794,"about_ca_system_score_gemma":0.0003920304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0265077,"about_ca_topic_score_gemma":0.0536963,"domain_scores_codex":[0.9998239,0.00004081685,0.000008755095,0.00006659226,0.00002695358,0.00003317339],"domain_scores_gemma":[0.9995179,0.00009023477,0.0002149262,0.00003544383,0.0001000286,0.00004136989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001203989,0.00002349735,0.98252,0.00002928682,0.0000355934,0.00008586027,0.00146176,0.0003936693,0.005068716,0.0001551766,0.0001362809,0.009969664],"study_design_scores_gemma":[0.000001161362,0.00001106866,0.9985721,0.000006380169,0.000005602311,0.00005565018,0.0006268077,0.0002522281,0.0001444184,0.00004945072,0.0002730325,0.000001931611],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992817,0.0001442784,0.00008833982,0.00004080417,0.000001720789,0.000002044221,0.00006700514,0.000001722405,0.0003725102],"genre_scores_gemma":[0.9995853,0.000133423,0.00008703798,0.00001713115,0.000004728787,0.000002652491,0.00007959081,0.000001112245,0.00008896117],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0265077,"threshold_uncertainty_score":0.05270684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03253323618358431,"score_gpt":0.2793474132726871,"score_spread":0.2468141770891028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}