{"id":"W2220760349","doi":"10.1073/pnas.1521651112","title":"Severe infectious diseases of childhood as monogenic inborn errors of immunity","year":2015,"lang":"en","type":"review","venue":"Proceedings of the National Academy of Sciences","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":220,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hospital for Sick Children","keywords":"Penetrance; Immunity; Biology; Infectious disease (medical specialty); Allele; Immunology; Genetics; Disease; Medicine; Gene; Phenotype; Immune system; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005979916,0.001136245,0.001433827,0.003148585,0.0003426972,0.0009343432,0.000885837,0.001188011,0.002157588],"category_scores_gemma":[0.001085962,0.0002651941,0.0004147876,0.002061594,0.0007883512,0.001679345,0.0007489509,0.002020015,0.001657417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006720796,"about_ca_system_score_gemma":0.001000584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009290201,"about_ca_topic_score_gemma":0.001959409,"domain_scores_codex":[0.9997692,0.00003571857,0.00004470211,0.00003785311,0.0000881225,0.00002454728],"domain_scores_gemma":[0.9994831,0.0002394399,0.00008797303,0.00001862989,0.0001122639,0.00005860424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"systematic_review","study_design_scores_codex":[0.00005434394,0.00004568309,0.0004393227,0.008165854,0.00007361794,0.0004844395,0.00007317654,0.0003108089,0.000651247,0.004932064,0.05236038,0.932409],"study_design_scores_gemma":[0.00001052279,0.00004775003,0.001172283,0.003048099,0.00007514592,0.005139729,0.0000817572,0.00006978014,0.0002194828,0.002496427,0.9876183,0.00002071677],"study_design_candidate":"systematic_review","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008740936,0.9982331,0.0001233474,0.0002702755,0.0004066535,0.000003454902,0.00001096723,0.000008844204,0.0008558373],"genre_scores_gemma":[0.000609101,0.998054,0.0001589895,0.0002598763,0.0004540188,0.000004096424,0.00002291095,0.000001573692,0.0004355098],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003148585,"threshold_uncertainty_score":0.007217884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03563671506776263,"score_gpt":0.3180431290858887,"score_spread":0.2824064140181261,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}