{"id":"W2220809577","doi":"10.1038/nbt.3294","title":"Directed differentiation of cholangiocytes from human pluripotent stem cells","year":2015,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"Pediatric Hepatobiliary Diseases and Treatments","field":"Medicine","cited_by":314,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; Hospital for Sick Children; University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University Health Network; Canadian Institutes of Health Research; Cystic Fibrosis Foundation Therapeutics; Cystic Fibrosis Foundation","keywords":"Induced pluripotent stem cell; Cystic fibrosis transmembrane conductance regulator; Biology; Cell biology; Stem cell; Cystic fibrosis; Cholangiocyte; Cilium; Cellular differentiation; Cancer research; Endocrinology; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003825804,0.0001335342,0.0002945252,0.0001756129,0.00002454878,0.000003915481,0.0001003935,0.0008194979,0.00002991324],"category_scores_gemma":[0.00003576775,0.0001037122,0.00009306106,0.0002244861,0.00005309411,0.00002837373,0.00005609827,0.0003408353,0.0000221457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009906267,"about_ca_system_score_gemma":0.00005911257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001845986,"about_ca_topic_score_gemma":0.00001600829,"domain_scores_codex":[0.9991478,0.00002324625,0.0002078209,0.0002608694,0.0001995652,0.0001606558],"domain_scores_gemma":[0.9992836,0.0000222807,0.000116665,0.0003616741,0.00009625954,0.0001195743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007635113,0.00328449,0.4626141,0.00015507,0.001313495,0.0003549577,0.000282744,0.000002730175,0.4629322,0.001548699,0.01203025,0.05471773],"study_design_scores_gemma":[0.005640654,0.0007631307,0.2833922,0.00006484483,0.0006142376,0.00001246496,0.0001410495,0.0002406439,0.7004982,0.0007081517,0.007677967,0.0002464536],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99366,0.004864269,0.00002628494,0.0004184566,0.0002386297,0.0002430311,0.0001168095,0.0002851948,0.0001473669],"genre_scores_gemma":[0.9989417,0.0001285694,0.000331297,0.00006724218,0.0001001022,0.000009344775,0.0001926676,0.00001426682,0.000214846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.237566,"threshold_uncertainty_score":0.6320719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428943956190336,"score_gpt":0.2612746332482628,"score_spread":0.2469851936863594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}