{"id":"W2220809577","doi":"10.1038/nbt.3294","title":"Directed differentiation of cholangiocytes from human pluripotent stem cells","year":2015,"lang":"en","type":"article","venue":"Nature Biotechnology","topic":"Pediatric Hepatobiliary Diseases and Treatments","field":"Medicine","cited_by":314,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; Hospital for Sick Children; University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; University Health Network; Canadian Institutes of Health Research; Cystic Fibrosis Foundation Therapeutics; Cystic Fibrosis Foundation","keywords":"Induced pluripotent stem cell; Cystic fibrosis transmembrane conductance regulator; Biology; Cell biology; Stem cell; Cystic fibrosis; Cholangiocyte; Cilium; Cellular differentiation; Cancer research; Endocrinology; Embryonic stem cell; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003570185,0.0002155417,0.0001605186,0.000232536,0.0001130931,0.0003203209,0.0001270344,0.0002547811,0.001477084],"category_scores_gemma":[0.0002005409,0.0001420017,0.0002138219,0.0001881546,0.0001180488,0.0001029104,0.0002406213,0.0005075197,0.0006133146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001125098,"about_ca_system_score_gemma":0.0002311595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002449674,"about_ca_topic_score_gemma":0.0006867714,"domain_scores_codex":[0.9998356,0.00003717935,0.00002824757,0.00002065251,0.00004903464,0.00002927551],"domain_scores_gemma":[0.9998928,0.00003035816,0.00001734695,0.00001845584,0.00002525397,0.00001562625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005727763,0.00001322901,0.0002013062,0.00005655,0.00000578376,0.0000753707,0.00003613496,0.0001329125,0.9952304,0.0005652388,0.0001316973,0.0034941],"study_design_scores_gemma":[0.0000209645,0.00007468207,0.0006356214,0.00001099406,0.00001646828,0.000163713,0.00001756008,0.0004451301,0.9924661,0.00009183931,0.006054476,0.000002589104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9303377,0.003317869,0.04510478,0.0004402597,0.0002647228,0.0003585286,0.001780419,0.0002254,0.01817048],"genre_scores_gemma":[0.9735973,0.00178245,0.01640339,0.0002119981,0.00002421654,0.0001087978,0.001275726,0.0000559109,0.006540179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001477084,"threshold_uncertainty_score":0.004941344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01428943956190336,"score_gpt":0.2612746332482628,"score_spread":0.2469851936863594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}