{"id":"W2220844398","doi":"10.1210/en.2015-1550","title":"Dual-Reporter β-Cell-Specific Male Transgenic Rats for the Analysis of β-Cell Functional Mass and Enrichment by Flow Cytometry","year":2015,"lang":"en","type":"article","venue":"Endocrinology","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research","keywords":"Transgene; Genetically modified mouse; Flow cytometry; Cell sorting; Reporter gene; Islet; Yellow fluorescent protein; Luciferase; Cell culture; Internal medicine; Biology; Green fluorescent protein; Secretion; Endocrinology; Insulin; In vivo; Cell biology; Chemistry; Molecular biology; Gene expression; Transfection; Gene; Biochemistry; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008275581,0.001233918,0.0007692553,0.00182644,0.0003491431,0.0006378957,0.001029934,0.0008816536,0.004602615],"category_scores_gemma":[0.0002490508,0.0005671995,0.0007142485,0.0006143159,0.0005031411,0.0006886412,0.0005268666,0.002843106,0.002433274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003925246,"about_ca_system_score_gemma":0.000386875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003825863,"about_ca_topic_score_gemma":0.0005652765,"domain_scores_codex":[0.9993217,0.00007489356,0.00007156678,0.0002288637,0.0001595371,0.000143425],"domain_scores_gemma":[0.9994747,0.00006169493,0.0001659055,0.00009424118,0.00007593152,0.000127648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000802745,0.00005621819,0.00009935444,0.00003055411,0.000004226042,0.00002440511,0.00001961049,0.00004290094,0.9978423,0.0002136894,0.00007179035,0.001514574],"study_design_scores_gemma":[0.00006367312,0.0004911441,0.001749729,0.00001753109,0.00004189842,0.0003383911,0.00002618193,0.001940523,0.989303,0.0001786949,0.005826448,0.00002272293],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5896722,0.003590325,0.3813369,0.0006532814,0.0004622379,0.001409634,0.009970228,0.005972993,0.006932237],"genre_scores_gemma":[0.5580217,0.006338744,0.3900334,0.000574767,0.0002311976,0.004746384,0.01053617,0.002029284,0.0274884],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004602615,"threshold_uncertainty_score":0.01539725,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03331658512481436,"score_gpt":0.2629925380886447,"score_spread":0.2296759529638303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}