{"id":"W2221232948","doi":"10.1038/nn.4209","title":"Hypothalamic feedforward inhibition of thalamocortical network controls arousal and consciousness","year":2015,"lang":"en","type":"article","venue":"Nature Neuroscience","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":282,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research","keywords":"Optogenetics; Neuroscience; Non-rapid eye movement sleep; Inhibitory postsynaptic potential; Arousal; Thalamic reticular nucleus; Sleep spindle; Neuroscience of sleep; GABAergic; Slow-wave sleep; Sleep (system call); Neurotransmission; Reticular activating system; Psychology; Biology; Eye movement; Reticular formation; Nucleus; Electroencephalography","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008296507,0.000246709,0.000127362,0.0001022267,0.0001518777,0.0004018701,0.0001845701,0.0001386174,0.001459869],"category_scores_gemma":[0.000410461,0.0001125454,0.0002025514,0.00005663927,0.0001847692,0.0001935255,0.0003007898,0.0002889699,0.000158924],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003386463,"about_ca_system_score_gemma":0.0002690566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008529539,"about_ca_topic_score_gemma":0.001619551,"domain_scores_codex":[0.9999413,0.000008862143,0.000003051701,0.00001242267,0.000012933,0.00002134332],"domain_scores_gemma":[0.9998868,0.00002848513,0.00001836285,0.000009618157,0.00002247719,0.00003428317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009860626,0.0001255792,0.01086811,0.00009779447,0.0001465066,0.000253375,0.0002314141,0.004074216,0.9037356,0.005886678,0.00139087,0.07220368],"study_design_scores_gemma":[0.0003049042,0.001730826,0.5038684,0.0001452027,0.0004123758,0.0007208586,0.0005442357,0.127246,0.3274525,0.0277772,0.009708935,0.00008851711],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9398676,0.001246153,0.04525512,0.0004828553,0.000376343,0.00003258495,0.0002494295,0.0002524795,0.01223746],"genre_scores_gemma":[0.9966021,0.0001779641,0.001770924,0.00004784129,0.00004057288,0.00001085012,0.00005309059,0.00002234216,0.001274268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001459869,"threshold_uncertainty_score":0.004883766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04035074246168133,"score_gpt":0.3057140935968851,"score_spread":0.2653633511352037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}