{"id":"W2221443629","doi":"10.2147/ijn.s90866","title":"Investigation and optimization of formulation parameters on preparation of targeted anti-CD205 tailored PLGA nanoparticles","year":2015,"lang":"en","type":"article","venue":"International Journal of Nanomedicine","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation; Canadian Light Source","keywords":"PLGA; Nanoparticle; Materials science; Nanotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003692199,0.0004419663,0.0002807292,0.0001974094,0.0001364322,0.0003402759,0.0002024859,0.0002658006,0.000629484],"category_scores_gemma":[0.0006464118,0.0001579821,0.0002037725,0.0002377849,0.0001711139,0.0003679749,0.0001527597,0.0003613574,0.0002187589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002673459,"about_ca_system_score_gemma":0.0002111605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004587238,"about_ca_topic_score_gemma":0.000985065,"domain_scores_codex":[0.9997244,0.00006533394,0.0000373168,0.00006900838,0.00006942436,0.00003435818],"domain_scores_gemma":[0.9997374,0.0000842447,0.00009977056,0.00001379443,0.00005049857,0.00001426279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001263472,0.00005694016,0.0001999752,0.0001363578,0.000008314343,0.00005275006,0.00003523381,0.0003616734,0.9963973,0.00003413447,0.00003464762,0.002556291],"study_design_scores_gemma":[0.000009410962,0.0003190695,0.0009923851,0.000009770148,0.00002847939,0.00006364118,0.00002283489,0.0007902026,0.9964546,0.00001417141,0.001287117,0.000008337269],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990656,0.003083399,0.004614985,0.0001019918,0.00004550222,0.00009615024,0.0001761117,0.00005546481,0.001170396],"genre_scores_gemma":[0.9847017,0.002891397,0.01103629,0.0000798137,0.00002097166,0.0001335081,0.0001604564,0.00005987127,0.0009159116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000629484,"threshold_uncertainty_score":0.002105832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1248658088577719,"score_gpt":0.4203621525442185,"score_spread":0.2954963436864467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}