{"id":"W2221693143","doi":"10.1074/jbc.m115.697599","title":"Negative Feed-forward Control of Tumor Necrosis Factor (TNF) by Tristetraprolin (ZFP36) Is Limited by the Mitogen-activated Protein Kinase Phosphatase, Dual-specificity Phosphatase 1 (DUSP1)","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Tristetraprolin; Dual-specificity phosphatase; Tumor necrosis factor alpha; Phosphatase; Protein kinase A; Kinase; MAP kinase kinase kinase; Cancer research; Chemistry; Cell biology; Biology; Biochemistry; Phosphorylation; Endocrinology; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001982392,0.0004858405,0.0003881185,0.000197562,0.0001962758,0.0003457651,0.0002353417,0.0002431132,0.001080151],"category_scores_gemma":[0.0001770293,0.0002450233,0.0004147067,0.0001900134,0.0003793278,0.000299177,0.0003229407,0.000603724,0.0003394721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005060681,"about_ca_system_score_gemma":0.0002310806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000664541,"about_ca_topic_score_gemma":0.000801671,"domain_scores_codex":[0.9996071,0.00004365568,0.00004100869,0.000144683,0.0001074841,0.00005605426],"domain_scores_gemma":[0.9997987,0.00003405032,0.00009212368,0.00002064346,0.0000231337,0.00003130914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004548308,0.000004229512,0.0001120839,0.00002273593,0.000002320789,0.0000210863,0.000009176621,0.00003667128,0.9990723,0.00004978379,0.00001507421,0.0006090045],"study_design_scores_gemma":[0.000006417838,0.00006686679,0.001975906,0.000002903453,0.000007893474,0.0001620523,0.000009932996,0.00067222,0.9957996,0.00004218523,0.001249647,0.000004369249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800987,0.003145316,0.01413397,0.0001615612,0.00007306348,0.00003387531,0.0006346331,0.0004336849,0.001285171],"genre_scores_gemma":[0.9921026,0.000670186,0.004824782,0.00004575705,0.000009033293,0.00003046502,0.0004429813,0.00003566691,0.001838533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001080151,"threshold_uncertainty_score":0.003671825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02343415335226545,"score_gpt":0.2506991552469024,"score_spread":0.227265001894637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}