{"id":"W222191070","doi":"10.1023/a:1020694425356","title":"A Randomized Phase II Study of Two Schedules of Bryostatin-1 (NSC339555) in Patients with Advanced Malignant Melanoma – A National Cancer Institute of Canada Clinical Trials Group Study","year":2002,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Nova Scotia Cancer Centre; Université de Montréal; Cancer Care Ontario; Hôpital Notre-Dame; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"National Cancer Institute","keywords":"Medicine; Nausea; myalgia; Adverse effect; Toxicity; Internal medicine; Lethargy; Phases of clinical research; Chemotherapy; Surgery; Clinical endpoint; Randomized controlled trial; Bryostatin 1; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002136332,0.002514516,0.004295888,0.0005918132,0.0006333128,0.001009724,0.001616779,0.001913511,0.007245608],"category_scores_gemma":[0.001380775,0.001051044,0.00200191,0.0007006677,0.002018472,0.001433942,0.0005134837,0.004997739,0.001303401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001656939,"about_ca_system_score_gemma":0.002620343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003735674,"about_ca_topic_score_gemma":0.008606678,"domain_scores_codex":[0.9992161,0.0003772867,0.00003209808,0.0001299495,0.00004612435,0.0001985227],"domain_scores_gemma":[0.9986659,0.0002310362,0.0002139345,0.0001723545,0.00005532978,0.0006614007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9628806,0.01822371,0.0006765426,0.0001480416,0.0005112707,0.00003337586,0.0000527773,0.0007200553,0.004001828,0.0001427536,0.001062642,0.01154642],"study_design_scores_gemma":[0.9031536,0.09405795,0.001418702,0.000005597107,0.0001979273,0.00001971026,0.00001895426,0.0002714225,0.0003197849,0.0001120571,0.0004113347,0.00001304174],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991254,0.001111135,0.0005087506,0.000742103,0.0003806676,0.003223668,0.001212688,0.00008901207,0.001478028],"genre_scores_gemma":[0.9828365,0.001557415,0.001859213,0.001252119,0.0005111734,0.005580193,0.002323646,0.00005054433,0.004029148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007245608,"threshold_uncertainty_score":0.02423894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05453415470042501,"score_gpt":0.3475556779144596,"score_spread":0.2930215232140346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}