{"id":"W222191070","doi":"10.1023/a:1020694425356","title":"A Randomized Phase II Study of Two Schedules of Bryostatin-1 (NSC339555) in Patients with Advanced Malignant Melanoma – A National Cancer Institute of Canada Clinical Trials Group Study","year":2002,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Nova Scotia Cancer Centre; Université de Montréal; Cancer Care Ontario; Hôpital Notre-Dame; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"National Cancer Institute","keywords":"Medicine; Nausea; myalgia; Adverse effect; Toxicity; Internal medicine; Lethargy; Phases of clinical research; Chemotherapy; Surgery; Clinical endpoint; Randomized controlled trial; Bryostatin 1; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001546638,0.0001853415,0.0008593593,0.00009413882,0.00004543916,0.00000391827,0.0001809127,0.0000583258,0.00004047514],"category_scores_gemma":[0.001423705,0.0001445553,0.00009509864,0.0001892808,0.0002041304,0.00001560177,0.00006954959,0.00008685182,1.835697e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000309162,"about_ca_system_score_gemma":0.001227219,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02404105,"about_ca_topic_score_gemma":0.06627604,"domain_scores_codex":[0.9966657,0.0006585095,0.00149764,0.0003421642,0.0006825292,0.0001534729],"domain_scores_gemma":[0.9980702,0.000249228,0.0009423253,0.0001985301,0.0004078767,0.000131832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.123186,0.03563856,0.7562999,0.0002188968,0.00364874,0.00002360427,0.006153713,0.008140611,0.04572913,0.00599556,0.003361975,0.01160334],"study_design_scores_gemma":[0.9170735,0.01029422,0.05209151,0.0002234042,0.0002854098,0.000001299476,0.000957241,0.0005721626,0.01670638,0.0008726034,0.0004169192,0.0005053542],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974664,0.0001612523,0.00004101255,0.00007370211,0.0002348318,0.001659006,0.0002547558,0.000002738999,0.0001063362],"genre_scores_gemma":[0.9980703,0.00001130356,0.001356285,0.00008239824,0.00008908803,0.0001223894,0.0001549893,0.00001331662,0.00009990211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7938874,"threshold_uncertainty_score":0.9824579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05453415470042501,"score_gpt":0.3475556779144596,"score_spread":0.2930215232140346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}