{"id":"W2222591283","doi":"10.1038/onc.2015.485","title":"Suppressor of cytokine signaling 1-dependent regulation of the expression and oncogenic functions of p21CIP1/WAF1 in the liver","year":2016,"lang":"en","type":"article","venue":"Oncogene","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Université de Sherbrooke","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Canadian Liver Foundation","keywords":"Suppressor of cytokine signaling 1; SOCS2; Biology; SOCS3; Cytokine; Suppressor of cytokine signalling; Cancer research; Tumor suppressor gene; Gene knockdown; SOCS6; Suppressor; Carcinogenesis; Downregulation and upregulation; Signal transduction; Cell biology; Apoptosis; Immunology; STAT3; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003089651,0.00008927869,0.0002199347,0.00009485687,0.00004458873,0.000002768023,0.00009821818,0.0000610248,0.0002865547],"category_scores_gemma":[0.0001350801,0.00004194076,0.0001137358,0.0001736855,0.0001020287,0.00006484519,0.00005376535,0.00008784024,0.000001902839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003101608,"about_ca_system_score_gemma":0.00005936515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001334687,"about_ca_topic_score_gemma":0.00004195602,"domain_scores_codex":[0.9989662,0.0001003357,0.0004057605,0.0001399633,0.000288492,0.0000993094],"domain_scores_gemma":[0.9989874,0.000240067,0.0002605063,0.0003402556,0.0001444029,0.00002734632],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001778615,0.0001743358,0.002789232,0.00004899859,0.0000257106,0.000001176192,0.0004889343,0.00004798987,0.9940375,0.00008061469,0.0002710274,0.001856618],"study_design_scores_gemma":[0.001118642,0.0002370285,0.01513285,0.0006164517,0.0001020524,0.00003518205,0.000256125,0.00007599183,0.9813597,0.00006380962,0.0009552639,0.00004690768],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975615,0.0003633502,0.0005612473,0.0004573185,0.0001052601,0.0002788924,0.00007029149,0.000005735046,0.0005964001],"genre_scores_gemma":[0.9992207,0.00007156294,0.0001746414,0.00003207486,0.00007762155,0.00001311285,0.00000550056,0.00001026195,0.0003945702],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01267781,"threshold_uncertainty_score":0.3137573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02579936461080412,"score_gpt":0.2624293414085712,"score_spread":0.236629976797767,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}