{"id":"W2223234570","doi":"10.1200/jco.2006.24.18_suppl.2078","title":"Dose escalation phase of a phase I/II study of GTI-2501, an antisense to the R1 subunit of ribonucleotide reductase (RNR) and docetaxel in patients with metastatic hormone-refractory prostate cancer","year":2006,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Docetaxel; Neutropenia; Prostate cancer; Internal medicine; Oncology; Toxicity; Cancer; Febrile neutropenia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001136535,0.001492289,0.001839698,0.0006256162,0.000580558,0.000924711,0.001097373,0.00115317,0.003272598],"category_scores_gemma":[0.0007561986,0.0007493379,0.0009831411,0.0005537613,0.001100947,0.0005693774,0.0003317941,0.003530687,0.000691944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002666899,"about_ca_system_score_gemma":0.00418302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00890501,"about_ca_topic_score_gemma":0.0209795,"domain_scores_codex":[0.9995621,0.0001491856,0.00001886461,0.0000816516,0.00005424039,0.0001340178],"domain_scores_gemma":[0.9993161,0.00008105389,0.0001024991,0.00005701298,0.00005709476,0.0003863691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5780454,0.2019182,0.01048248,0.0006511596,0.0008658504,0.0004746012,0.0009151594,0.006538042,0.09724211,0.0004344503,0.006549896,0.09588262],"study_design_scores_gemma":[0.3812729,0.5854378,0.01872378,0.00003305534,0.0003325126,0.0002885717,0.00008823151,0.001504202,0.008478683,0.0002074698,0.003587225,0.00004557076],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907362,0.0006040849,0.0004161574,0.0003019003,0.00006239906,0.005137962,0.001077961,0.0000757005,0.00158769],"genre_scores_gemma":[0.9874309,0.0006498108,0.002136362,0.0006912881,0.0001039047,0.004263818,0.002026469,0.00003440923,0.002662967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00890501,"threshold_uncertainty_score":0.01934987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08929568132442707,"score_gpt":0.4910764131477676,"score_spread":0.4017807318233405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}