{"id":"W2223761815","doi":"10.1016/s0923-7534(20)31970-0","title":"Randomized Phase 3 Trial of Regorafenib in Patients (Patients) with Metastatic and/or Unresectable Gastrointestinal Stromal Tumor (GIST) Progressing Despite Prior Treatment with at Least Imatinib (IM) and Sunitinib (SU) : Grid Trial","year":2012,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Gastrointestinal Tumor Research and Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"Regorafenib; Medicine; GiST; Sunitinib; Imatinib; Oncology; Internal medicine; Sunitinib malate; Stromal tumor; Stromal cell; Colorectal cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009696358,0.0003852133,0.00177653,0.0003184911,0.00009920462,0.00002007351,0.00007613289,0.00003350529,0.00007156061],"category_scores_gemma":[0.001031905,0.0002199244,0.0001207808,0.0002408931,0.0008489217,0.0002123214,0.00008060896,0.0001913816,0.000001626675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001617461,"about_ca_system_score_gemma":0.0005377571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001795581,"about_ca_topic_score_gemma":0.0001042541,"domain_scores_codex":[0.9966828,0.0006697766,0.0009197001,0.0003785407,0.0005537493,0.0007954685],"domain_scores_gemma":[0.996969,0.0009952856,0.0008195632,0.0002523566,0.0004757361,0.0004880244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8440835,0.01578028,0.1303951,0.0001761266,0.0002740743,0.0002346926,0.0002506281,0.000001090659,0.00005368179,0.00001456755,0.00001939271,0.008716793],"study_design_scores_gemma":[0.7552633,0.2294004,0.01308499,0.000540957,0.0003985889,0.0003654183,0.0001454785,0.00004482883,0.0005720587,0.000005144434,0.00005598224,0.0001228294],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931145,0.0001439824,0.00001978839,0.0002278979,0.00004054303,0.00613253,0.000104449,0.00001608931,0.0002002446],"genre_scores_gemma":[0.9874417,0.00001918703,0.01180464,0.00002363324,0.00008171662,0.0003557841,0.0001581584,0.00003635072,0.00007882273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2136201,"threshold_uncertainty_score":0.8968257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09573382842189562,"score_gpt":0.3966884140924295,"score_spread":0.3009545856705339,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}