{"id":"W2223807461","doi":"10.1016/j.coi.2015.12.006","title":"Melanoma: the intersection of molecular targeted therapy and immune checkpoint inhibition","year":2016,"lang":"en","type":"review","venue":"Current Opinion in Immunology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Bristol-Myers Squibb Canada","keywords":"Melanoma; Immune checkpoint; Targeted therapy; Blockade; Immune system; Medicine; Cancer research; Immunotherapy; Immunology; Cancer; Internal medicine; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00071337,0.0007006443,0.001354911,0.0009430256,0.0002127005,0.00116211,0.0008989808,0.001430158,0.002557835],"category_scores_gemma":[0.000541813,0.000214171,0.0004138308,0.0007924323,0.0006588566,0.00145834,0.0007227933,0.003596947,0.001430229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007553811,"about_ca_system_score_gemma":0.0007499529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005001122,"about_ca_topic_score_gemma":0.001552702,"domain_scores_codex":[0.9998201,0.00003107457,0.0000174759,0.00003193965,0.000073283,0.00002615023],"domain_scores_gemma":[0.9997827,0.00009307078,0.00003203491,0.000007964703,0.00005108766,0.0000330186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002020439,0.0001127603,0.0001685768,0.007402135,0.00007056729,0.0002750625,0.00003374528,0.0005054585,0.005873893,0.009259713,0.04797899,0.9281171],"study_design_scores_gemma":[0.00005656253,0.0001431173,0.0006375671,0.001512965,0.00008792424,0.001183587,0.00004152487,0.0002415396,0.001345648,0.00520586,0.989521,0.00002267541],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001422343,0.9970437,0.0002791681,0.001094814,0.000483427,0.000004771025,0.00001346909,0.00001123315,0.0009272313],"genre_scores_gemma":[0.001591791,0.9958168,0.0002827768,0.0008400179,0.0005540246,0.000009544784,0.00002985413,0.00000222465,0.0008731057],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002557835,"threshold_uncertainty_score":0.008556843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04236795058960134,"score_gpt":0.3149179662027996,"score_spread":0.2725500156131982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}