{"id":"W2223865021","doi":"10.1007/s12035-015-9515-5","title":"Mechanisms of Mitochondrial Dysfunction in Alzheimer’s Disease","year":2015,"lang":"en","type":"review","venue":"Molecular Neurobiology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":230,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Boniface Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; University of Manitoba","keywords":"Mitochondrion; Oxidative phosphorylation; Bioenergetics; Electron transport chain; Adenosine triphosphate; ATP synthase; Cell biology; Respiratory chain; Biology; Biochemistry; Nicotinamide adenine dinucleotide; Chemistry; NAD+ kinase; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006804885,0.000990247,0.001502304,0.001900764,0.0003096198,0.001147289,0.001282841,0.001384525,0.002213427],"category_scores_gemma":[0.0005888043,0.0002698787,0.0003701615,0.00175566,0.0007061788,0.001573291,0.001012149,0.00166699,0.001156892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007744063,"about_ca_system_score_gemma":0.001072474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001080129,"about_ca_topic_score_gemma":0.002019226,"domain_scores_codex":[0.9998643,0.00002007517,0.00002395841,0.00002387156,0.0000504023,0.00001734387],"domain_scores_gemma":[0.999791,0.00007141599,0.00004081457,0.000006875017,0.00006199341,0.00002798916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001226509,0.00006824305,0.0002256775,0.01559293,0.00008792197,0.0004905786,0.0000637343,0.0005003958,0.002455096,0.005552127,0.0339824,0.9408583],"study_design_scores_gemma":[0.00003490813,0.00009082935,0.001225321,0.0047791,0.0002115212,0.002817266,0.0001052955,0.0001853712,0.0008090067,0.007763583,0.9819422,0.00003553056],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007031739,0.999065,0.0001190886,0.0002390624,0.0001548944,0.000002172279,0.0000109344,0.000004055708,0.0003345882],"genre_scores_gemma":[0.0004944918,0.9987953,0.0001201885,0.0001018433,0.0001960662,0.000003055575,0.00001520733,5.472857e-7,0.0002732676],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002213427,"threshold_uncertainty_score":0.007404625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03737785026378235,"score_gpt":0.3009501363133317,"score_spread":0.2635722860495493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}