{"id":"W2223928115","doi":"10.1093/hmg/ddv338","title":"High-dose folic acid supplementation alters the human sperm methylome and is influenced by the<i>MTHFR</i>C677T polymorphism","year":2015,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Montreal Children's Hospital; Health Canada; McGill University Health Centre; McGill University and Génome Québec Innovation Centre","funders":"Institute of Human Development, Child and Youth Health; McGill University Health Centre; Canadian Institutes of Health Research; Université de Montréal; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Biology; DNA methylation; Epigenome; Methylenetetrahydrofolate reductase; Sperm; Methylation; Epigenetics; CpG site; Genetics; Andrology; Allele; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004042515,0.0003053957,0.0001896727,0.00005476979,0.0003605206,0.0001432993,0.0004217096,0.0001685645,0.0000292228],"category_scores_gemma":[0.00003482669,0.0002356875,0.0001003072,0.0001332434,0.000276583,0.000006937604,0.0002490035,0.00015787,0.000009870494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002715391,"about_ca_system_score_gemma":0.00005602582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002426822,"about_ca_topic_score_gemma":0.00008803699,"domain_scores_codex":[0.9980763,0.0002345122,0.0004090298,0.0005056411,0.0003958796,0.0003786035],"domain_scores_gemma":[0.9986794,0.00001294749,0.0001929378,0.0007858364,0.0001455928,0.0001833006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001324939,0.00003372306,0.001172072,0.000006293446,0.00007733393,0.000002708239,0.0004939773,0.0001019719,0.9936925,0.000418495,0.002584699,0.001403015],"study_design_scores_gemma":[0.001322374,0.0004475527,0.00479629,0.000005941294,0.0001060264,0.000006668819,0.0002641847,0.00003045422,0.9733464,0.00359519,0.01573675,0.0003421777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869193,0.009291908,0.00194016,0.000860275,0.0001232225,0.000478974,0.00005556162,0.00001433829,0.0003162948],"genre_scores_gemma":[0.9958814,0.0004877682,0.0006829933,0.001882657,0.0001926698,0.00005335569,0.0004536091,0.00005913366,0.0003064587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02034608,"threshold_uncertainty_score":0.9611055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02014554492797595,"score_gpt":0.2952536345825131,"score_spread":0.2751080896545371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}