{"id":"W2223928115","doi":"10.1093/hmg/ddv338","title":"High-dose folic acid supplementation alters the human sperm methylome and is influenced by the<i>MTHFR</i>C677T polymorphism","year":2015,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill Genome Centre; Montreal Children's Hospital; Health Canada; McGill University Health Centre; McGill University and Génome Québec Innovation Centre","funders":"Institute of Human Development, Child and Youth Health; McGill University Health Centre; Canadian Institutes of Health Research; Université de Montréal; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Biology; DNA methylation; Epigenome; Methylenetetrahydrofolate reductase; Sperm; Methylation; Epigenetics; CpG site; Genetics; Andrology; Allele; Gene; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001335388,0.0001251779,0.0001907617,0.0002977923,0.0001627539,0.000135654,0.00008770274,0.0002724716,0.001357811],"category_scores_gemma":[0.0002359495,0.0001411247,0.0001608086,0.0002364945,0.0001386605,0.00005422304,0.0001062757,0.000126461,0.0001435355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000184114,"about_ca_system_score_gemma":0.0001382189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004494768,"about_ca_topic_score_gemma":0.003934882,"domain_scores_codex":[0.9998981,0.00003090558,0.000007650068,0.0000264587,0.00002229479,0.00001468122],"domain_scores_gemma":[0.9999243,0.00001599956,0.00002996927,0.000007222153,0.00001132014,0.00001120387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002602051,0.00008076187,0.0932778,0.00009174948,0.0001616394,0.0004250398,0.0002139643,0.0002093398,0.886803,0.0000698482,0.0002004224,0.0158644],"study_design_scores_gemma":[0.00007916108,0.001755309,0.8780051,0.00001943009,0.0001908267,0.00137025,0.0001645278,0.000702348,0.1155234,0.0001166667,0.002060044,0.00001281611],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983453,0.00103303,0.0001786284,0.00003928611,0.000002931986,0.000005143509,0.0001656566,0.000007518011,0.0002224928],"genre_scores_gemma":[0.9988561,0.0002845595,0.0001373179,0.00002821651,0.000002058848,0.000003627132,0.0001446971,0.000002695129,0.0005408747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004494768,"threshold_uncertainty_score":0.00893718,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02014554492797595,"score_gpt":0.2952536345825131,"score_spread":0.2751080896545371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}