{"id":"W2224037267","doi":"10.3389/fphar.2015.00303","title":"Hepatoprotective and Anti-fibrotic Agents: It's Time to Take the Next Step","year":2016,"lang":"en","type":"review","venue":"Frontiers in Pharmacology","topic":"Liver physiology and pathology","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"RWTH Aachen University; Deutsche Forschungsgemeinschaft; Government of Canada","keywords":"Cirrhosis; Medicine; Disease; European union; Pharmacology; Animal testing; Mode of action; Animal model; Member states; Drug; Bioinformatics; Pathology; Toxicology; Internal medicine; Biology; Business","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0004520817,0.0004640576,0.002160507,0.0003920131,0.0001098084,0.000008783692,0.0003510977,0.0006277817,0.001196614],"category_scores_gemma":[0.00007727623,0.0002738973,0.00022978,0.0003251132,0.0004845058,0.00006864613,0.0002585966,0.0008974628,0.001087531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001930162,"about_ca_system_score_gemma":0.0002613224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005884627,"about_ca_topic_score_gemma":6.563484e-7,"domain_scores_codex":[0.9969963,0.001081472,0.0005157051,0.0007244626,0.0001072291,0.0005747749],"domain_scores_gemma":[0.9988605,0.0003135085,0.0002244339,0.0003672028,0.00005174898,0.0001826464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001971415,0.00009902735,0.000115458,0.002272815,0.0007928906,0.0004230666,0.0002075044,3.032614e-7,0.0001000162,0.00001191161,0.3447724,0.6510075],"study_design_scores_gemma":[0.001121412,0.000319889,0.0001899673,0.001872455,0.001187287,0.0003632986,0.00002776153,0.00001844535,0.000009338963,0.00007798386,0.9945347,0.0002774166],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002116039,0.9901101,0.0002708947,0.001571888,0.002725602,0.003550188,0.00006462498,0.00004264506,0.00145244],"genre_scores_gemma":[0.00004979234,0.9899544,0.0006951219,0.004789693,0.0006497498,0.0005716266,0.00003318871,0.00005865679,0.003197764],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.65073,"threshold_uncertainty_score":0.9999713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04779340971525296,"score_gpt":0.3518523770803915,"score_spread":0.3040589673651385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}