{"id":"W2224231996","doi":"10.1016/j.bbamem.2013.02.005","title":"Structural features of the apelin receptor N-terminal tail and first transmembrane segment implicated in ligand binding and receptor trafficking","year":2013,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"Apelin-related biomedical research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Nova Scotia Health Research Foundation; Natural Sciences and Engineering Research Council of Canada; Dalhousie Medical Research Foundation","keywords":"Apelin; G protein-coupled receptor; Chemistry; Transmembrane protein; Transmembrane domain; Receptor; HEK 293 cells; Biophysics; Ligand (biochemistry); Biochemistry; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003630947,0.0005126051,0.0007817245,0.0004563929,0.0002257691,0.0001183591,0.0004152211,0.0004440238,0.0001357655],"category_scores_gemma":[0.0001740342,0.0003325518,0.0001909701,0.00120438,0.001160335,0.0002249596,0.0002336491,0.0007554553,0.0000233922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009128607,"about_ca_system_score_gemma":0.000157435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003213915,"about_ca_topic_score_gemma":0.00003111593,"domain_scores_codex":[0.9967731,0.0001639583,0.0007665045,0.0008140497,0.000754175,0.0007281899],"domain_scores_gemma":[0.9982977,0.0003785707,0.0002685983,0.0005069885,0.0001386395,0.0004095191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004429311,0.0001761635,0.0001417076,0.0007184187,0.0001357194,0.00000630461,0.001296248,4.897167e-7,0.9898485,0.00001467968,0.0006052937,0.006613531],"study_design_scores_gemma":[0.003071496,0.0004763338,0.1189268,0.0009599776,0.0001205484,0.0001103641,0.0005067284,0.0003987782,0.8746399,0.00002381165,0.000329638,0.0004356345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805594,0.0004838499,6.149056e-7,0.01705836,0.0001930719,0.001466591,0.0001063681,0.00007392743,0.00005782331],"genre_scores_gemma":[0.9975954,0.001198752,0.0002563602,0.0002506092,0.0001987822,0.0000614246,0.0001236392,0.00006645983,0.0002486208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1187851,"threshold_uncertainty_score":0.9999127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456962167611489,"score_gpt":0.2678608537126997,"score_spread":0.2532912320365849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}