{"id":"W2224640355","doi":"10.1016/j.cmet.2015.12.007","title":"Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism","year":2016,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":96,"is_retracted":false,"has_abstract":false,"ca_institutions":"International Collaboration On Repair Discoveries; University of British Columbia","funders":"Motor Neurone Disease Association; Vlaamse regering; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Fonds Wetenschappelijk Onderzoek; Australian Government","keywords":"Neuroprotection; Ischemia; Pentose phosphate pathway; Glycolysis; Metabolism; Brain ischemia; Biology; Biochemistry; Medicine; Pharmacology; Chemistry; Endocrinology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003780261,0.0003074222,0.0004639668,0.00009219173,0.0000920677,0.00001349988,0.0003111436,0.0002515449,0.00003573301],"category_scores_gemma":[0.000215106,0.0001865156,0.0003744484,0.0002377548,0.000252746,0.00001884973,0.0002147901,0.0001562558,0.000006429542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001148364,"about_ca_system_score_gemma":0.0001780742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003466661,"about_ca_topic_score_gemma":0.00001579481,"domain_scores_codex":[0.9978533,0.000195072,0.0005840095,0.0005709041,0.000385459,0.0004112569],"domain_scores_gemma":[0.9981917,0.00002515291,0.000547295,0.0008302419,0.00029171,0.0001139635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002414175,0.0001014461,0.00003884639,0.00007015565,0.00005673677,5.022172e-7,0.00006455447,0.00001109019,0.9620317,0.00004553334,0.0007872172,0.03655086],"study_design_scores_gemma":[0.00126418,0.00003888155,0.001910842,0.00003256902,0.00009323441,0.000007606301,0.00003003505,0.000005634907,0.7194218,0.00002787229,0.2769868,0.0001805133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892711,0.005351585,0.002176849,0.0001371078,0.001383702,0.000735515,0.0001268101,0.00002242697,0.0007948763],"genre_scores_gemma":[0.9920526,0.001848317,0.001605055,0.000194753,0.001677455,0.00009708311,0.00003065831,0.00006007264,0.002434059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2761996,"threshold_uncertainty_score":0.7605885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00918478021473479,"score_gpt":0.2155860412417372,"score_spread":0.2064012610270025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}