{"id":"W2224694966","doi":"10.3109/14756366.2015.1118685","title":"Novel inhibitors of the methicillin-resistant <i>Staphylococcus aureus</i> (MRSA)-pyruvate kinase","year":2015,"lang":"en","type":"article","venue":"Journal of Enzyme Inhibition and Medicinal Chemistry","topic":"Synthesis of Indole Derivatives","field":"Chemistry","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Staphylococcus aureus; Methicillin-resistant Staphylococcus aureus; Chemistry; Indole test; Microbiology; Structure–activity relationship; Antimicrobial; Enzyme; Biochemistry; Stereochemistry; Bacteria; Biology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008273288,0.000321572,0.0001584281,0.0001565371,0.00008386151,0.0001551591,0.0002164675,0.0001188743,0.001200292],"category_scores_gemma":[0.00007578015,0.0000935969,0.0001391289,0.0001117328,0.00009198556,0.0001577327,0.00011708,0.000338334,0.0002977432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001769715,"about_ca_system_score_gemma":0.0001868171,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00029533,"about_ca_topic_score_gemma":0.001015784,"domain_scores_codex":[0.9999584,0.000006811385,0.000004229051,0.000005969118,0.000009640189,0.00001504563],"domain_scores_gemma":[0.9999688,0.000004309562,0.000009187273,0.000001605866,0.000005623694,0.00001053327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002826524,0.0001598135,0.0001937753,0.0001601829,0.00001145597,0.0001594784,0.00003868855,0.0005464628,0.9821293,0.0004467541,0.0001934778,0.01567792],"study_design_scores_gemma":[0.0001915193,0.002327766,0.002687767,0.00002055347,0.00003551017,0.0004682605,0.00002268052,0.0008323578,0.9811709,0.0001028002,0.0121256,0.00001424124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9623821,0.0162038,0.01066327,0.0002063691,0.0001283604,0.0003122099,0.000860591,0.0002135643,0.009029648],"genre_scores_gemma":[0.9761941,0.008678662,0.01029849,0.0001241075,0.00004319846,0.000118119,0.0005941729,0.00002499639,0.003924093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001200292,"threshold_uncertainty_score":0.004015386,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02629130588266451,"score_gpt":0.2541318699016923,"score_spread":0.2278405640190278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}