{"id":"W2225056762","doi":"10.1038/srep18092","title":"Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; St Joseph's Health Care; McGill University","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; University of California, San Diego; National Institutes of Health; National Institute of Neurological Disorders and Stroke; IXICO; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Biogen; BioClinica; Medpace; F. Hoffmann-La Roche; Bristol-Myers Squibb; U.S. Department of Defense; Eli Lilly and Company; BrightFocus Foundation; Novartis Pharmaceuticals Corporation; Hope Center for Neurological Disorders; University of Southern California; Wellcome Trust; Synarc; Foundation for the National Institutes of Health; American Federation for Aging Research; Alzheimer's Association; Genentech; National Multiple Sclerosis Society; Alzheimer's Disease Neuroimaging Initiative; Medical Research Council; Meso Scale Diagnostics","keywords":"Genome-wide association study; Biology; Genetics; Genetic association; Disease; Gene; Locus (genetics); Apolipoprotein E; Genetic architecture; Quantitative trait locus; Genotype; Single-nucleotide polymorphism; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001564553,0.0006004028,0.0004240982,0.001382401,0.000287392,0.0006221685,0.0002787131,0.0005877001,0.001411988],"category_scores_gemma":[0.003375982,0.00019959,0.0003748133,0.001803957,0.0007153738,0.0002644806,0.000518469,0.0005918973,0.0001976168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000178951,"about_ca_system_score_gemma":0.0002135155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006286564,"about_ca_topic_score_gemma":0.0005027597,"domain_scores_codex":[0.9988891,0.0004564509,0.00007987057,0.0003095578,0.0001994217,0.00006550687],"domain_scores_gemma":[0.9966244,0.001691194,0.001205974,0.0002060424,0.0001189785,0.0001534432],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001019149,0.0001162173,0.9416308,0.00006998966,0.0007547013,0.001046612,0.0002802036,0.0004604573,0.0433143,0.000554111,0.0001326666,0.0106208],"study_design_scores_gemma":[0.00003034967,0.0002080962,0.9922184,0.000009632296,0.0001450307,0.001411902,0.00007449841,0.0008801685,0.003845603,0.0007653654,0.0003979823,0.00001289016],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969362,0.0005795005,0.001770503,0.0001086865,0.000008045974,0.000007532645,0.0002292864,0.00001793695,0.0003423188],"genre_scores_gemma":[0.9980247,0.0001954997,0.001444394,0.00003013366,0.00001623612,0.000007913186,0.0001197118,0.000007115937,0.0001543044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001564553,"threshold_uncertainty_score":0.008274198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0427894757629773,"score_gpt":0.3211029847188626,"score_spread":0.2783135089558853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}