{"id":"W2225075683","doi":"10.1161/res.115.suppl_1.176","title":"Abstract 176: Saxagliptin and Tadalafil Differentially Alter Global and Cellular Cardiac Function in a Translational Miniature Swine Model of Left Ventricle Hypertrophy","year":2014,"lang":"en","type":"article","venue":"Circulation Research","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Gibson Energy (Canada)","funders":"","keywords":"Internal medicine; Contractility; Muscle hypertrophy; Ventricle; Heart failure; Medicine; Cardiology; Ejection fraction; Diastole; Pressure overload; Heart failure with preserved ejection fraction; Tadalafil; Cardiac function curve; Preload; Endocrinology; Blood pressure; Hemodynamics; Cardiac hypertrophy; Sildenafil","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004436621,0.0006925236,0.0006923305,0.0004568475,0.000335751,0.0005143184,0.0005630608,0.0008644666,0.002907207],"category_scores_gemma":[0.0001796698,0.0003564638,0.0007406203,0.0002032639,0.0006413907,0.0006247078,0.0003146344,0.001814866,0.0008138857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004190974,"about_ca_system_score_gemma":0.0005419623,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005226033,"about_ca_topic_score_gemma":0.001130229,"domain_scores_codex":[0.9996673,0.00004814815,0.00004900727,0.00008291658,0.00006509897,0.000087634],"domain_scores_gemma":[0.9996351,0.0000253571,0.00008159016,0.00004661679,0.00002930983,0.0001820219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005084677,0.001807661,0.0007225125,0.0001068516,0.00003341701,0.0001660476,0.00005446991,0.0000826207,0.9881947,0.0001833015,0.0003442214,0.003219446],"study_design_scores_gemma":[0.00282708,0.05626141,0.03179148,0.00005890569,0.0002644785,0.0008286443,0.0004084898,0.004011755,0.8950213,0.0002826794,0.008190742,0.00005306993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960115,0.0005196703,0.001062222,0.0003276777,0.0002038927,0.000107946,0.0007527022,0.00007349403,0.0009408469],"genre_scores_gemma":[0.9827616,0.0009635238,0.003598062,0.000676188,0.000113073,0.0006448479,0.002640661,0.00006265182,0.008539531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002907207,"threshold_uncertainty_score":0.00972563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02148821519640751,"score_gpt":0.2710960636399948,"score_spread":0.2496078484435873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}