{"id":"W2225224982","doi":"10.1534/g3.115.021915","title":"Genome-Wide Mutational Signature of the Chemotherapeutic Agent Mitomycin C in<i>Caenorhabditis elegans</i>","year":2015,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Caenorhabditis elegans; Genetics; DNA; Mitomycin C; DNA damage; Genome; DNA repair; genomic DNA; DNA sequencing; Context (archaeology); Gene; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001149098,0.0001712501,0.0001482977,0.0005719248,0.0002047406,0.0001698337,0.0001352712,0.000217996,0.0006908561],"category_scores_gemma":[0.0001526096,0.0001051527,0.0001616341,0.0002212117,0.0001469158,0.0000650211,0.0001354576,0.0002960799,0.00009550585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002410011,"about_ca_system_score_gemma":0.0001627099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002200033,"about_ca_topic_score_gemma":0.005015286,"domain_scores_codex":[0.9998966,0.00001002776,0.000008776466,0.00004298512,0.00002754235,0.00001401773],"domain_scores_gemma":[0.9998568,0.00002518399,0.00006146681,0.00001386345,0.00001907652,0.00002353633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000448914,0.00001028325,0.001875377,0.0000214947,0.000008002929,0.0000248953,0.000007931876,0.00005818583,0.9968717,0.00001694558,0.00003481911,0.001025489],"study_design_scores_gemma":[0.0000102015,0.0003123376,0.3998259,0.00001833775,0.00008630176,0.0006449968,0.00007507278,0.001453687,0.5953973,0.0000572095,0.002101709,0.00001691884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960957,0.0004148534,0.001109317,0.00002693111,0.000007020097,0.00002784234,0.001653575,0.00006498231,0.0005997674],"genre_scores_gemma":[0.9956756,0.0002648471,0.001814725,0.00003464816,0.00000213332,0.00002514088,0.001518931,0.00001817331,0.0006458669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002200033,"threshold_uncertainty_score":0.004374385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200190255999062,"score_gpt":0.2297955188752632,"score_spread":0.2177936163152726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}