{"id":"W2225252038","doi":"10.1016/j.bmcl.2016.01.005","title":"1-[3-(2-Hydroxyethylsulfanyl)propanoyl]-3,5-bis(benzylidene)-4-piperidones: A novel cluster of P-glycoprotein dependent multidrug resistance modulators","year":2016,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Multiple drug resistance; P-glycoprotein; Chemistry; Cytotoxicity; Stereochemistry; Pharmacology; In vitro; Biochemistry; Medicine; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001311122,0.0002997698,0.0003240099,0.0002036861,0.0002028989,0.0002396619,0.0005052039,0.0002329115,0.001396725],"category_scores_gemma":[0.0001084304,0.000122603,0.0001132284,0.0001592605,0.0001611129,0.0002291545,0.0002951329,0.0004568436,0.000680736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003436032,"about_ca_system_score_gemma":0.0002634608,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003073557,"about_ca_topic_score_gemma":0.0004782742,"domain_scores_codex":[0.9999272,0.00001928052,0.000003831379,0.00001433684,0.00001693044,0.00001845383],"domain_scores_gemma":[0.9999601,0.000004508438,0.000009832263,0.000004250869,0.000007669542,0.0000138259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009303383,0.0001769869,0.0002320047,0.0002217208,0.0000165504,0.0003013681,0.0001044174,0.001219609,0.9553446,0.003538196,0.002011453,0.0359028],"study_design_scores_gemma":[0.0004318817,0.004634297,0.004183154,0.00003453721,0.00005611506,0.001085448,0.00006521813,0.006417831,0.9111867,0.000712578,0.07115052,0.00004160289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9411713,0.01546822,0.02276623,0.0008330131,0.0002845429,0.0002216745,0.0008473255,0.0009837335,0.01742397],"genre_scores_gemma":[0.9709202,0.006763734,0.01200409,0.0001975383,0.0000786596,0.0002378367,0.0006626421,0.00004735841,0.009087912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001396725,"threshold_uncertainty_score":0.004672468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007699560830480326,"score_gpt":0.2095227390789358,"score_spread":0.2018231782484555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}