{"id":"W2225639217","doi":"10.1371/journal.ppat.1005349","title":"TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":325,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute on Minority Health and Health Disparities; Office of AIDS Research; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; University of California, San Francisco; National Institutes of Health; International AIDS Society; Bristol-Myers Squibb","keywords":"TIGIT; Cytotoxic T cell; Immunology; CD8; Biology; T cell; Immune system; Cancer research; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317408,0.0002315822,0.0001810029,0.0005766582,0.0001581511,0.0004056616,0.0002032422,0.0002950767,0.001485903],"category_scores_gemma":[0.0002025948,0.0001133947,0.0001327327,0.0002066519,0.0002351555,0.0002054256,0.000198837,0.0005246451,0.000292218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002603346,"about_ca_system_score_gemma":0.0001133024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002238099,"about_ca_topic_score_gemma":0.0002378309,"domain_scores_codex":[0.9999167,0.0000120812,0.000005736446,0.00001995919,0.00002026117,0.00002534967],"domain_scores_gemma":[0.9999323,0.000008828843,0.00002040055,0.000007540239,0.000008087042,0.00002279377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002316779,0.00002353616,0.003635246,0.00002916045,0.000006657655,0.0001403421,0.00004069132,0.00008123092,0.9907017,0.0001644218,0.0000706162,0.004874784],"study_design_scores_gemma":[0.00002667277,0.001156082,0.1798037,0.00003653741,0.00006251407,0.00524406,0.0002481075,0.00204021,0.8026593,0.0007533806,0.007948145,0.00002128978],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933918,0.003614957,0.001297996,0.0000479398,0.00001475039,0.00001005911,0.0001379911,0.00007904223,0.001405423],"genre_scores_gemma":[0.997042,0.0006719524,0.0007539428,0.00002219824,0.00001045496,0.0000118395,0.0001612753,0.000008608315,0.001317811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001485903,"threshold_uncertainty_score":0.004970849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00833244263356661,"score_gpt":0.2167104029470557,"score_spread":0.208377960313489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}