{"id":"W2225639217","doi":"10.1371/journal.ppat.1005349","title":"TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection","year":2016,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":325,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute on Minority Health and Health Disparities; Office of AIDS Research; National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; University of California, San Francisco; National Institutes of Health; International AIDS Society; Bristol-Myers Squibb","keywords":"TIGIT; Cytotoxic T cell; Immunology; CD8; Biology; T cell; Immune system; Cancer research; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010517,0.0001403855,0.0001541986,0.0001169279,0.0001402126,0.00002099869,0.00002756381,0.0001334947,0.0001676096],"category_scores_gemma":[0.0001044544,0.00009269987,0.00002725372,0.00007281171,0.00008761834,0.0002416029,0.00002683555,0.0001042642,0.00005637326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003409792,"about_ca_system_score_gemma":0.00003208595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001346283,"about_ca_topic_score_gemma":0.00001370742,"domain_scores_codex":[0.999234,0.0001018213,0.0002062127,0.0002562394,0.00002597638,0.0001757069],"domain_scores_gemma":[0.999537,0.00009768304,0.0001171626,0.0001297869,0.0000893994,0.00002898252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001995234,0.0001910523,0.0791479,0.00005669923,0.00005558411,0.000004237128,0.0002012597,0.000003076408,0.9146708,0.00009082191,0.001067015,0.002516297],"study_design_scores_gemma":[0.009949077,0.002646394,0.3511722,0.001314047,0.0002754277,0.0001052639,0.0003599891,0.0004445868,0.5702903,0.0004539647,0.06218177,0.0008069577],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968065,0.00123086,0.0004199577,0.0003584237,0.0004234843,0.0005534047,0.00002215471,0.00005943577,0.0001257689],"genre_scores_gemma":[0.9937977,0.0002376469,0.0001038105,0.00003921278,0.00001891284,0.0001430137,0.0001812289,0.0000184624,0.005460015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3443806,"threshold_uncertainty_score":0.3780191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00833244263356661,"score_gpt":0.2167104029470557,"score_spread":0.208377960313489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}