{"id":"W2225668990","doi":"10.1021/acs.bioconjchem.5b00609","title":"<sup>125</sup>I-Tetrazines and Inverse-Electron-Demand Diels–Alder Chemistry: A Convenient Radioiodination Strategy for Biomolecule Labeling, Screening, and Biodistribution Studies","year":2015,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Centre for Probe Development and Commercialization","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Institute for Cancer Research","keywords":"Biodistribution; Chemistry; Bioorthogonal chemistry; Tetrazine; Biomolecule; Halogenation; Combinatorial chemistry; Iodine; Radiochemistry; Organic chemistry; In vitro; Click chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003055575,0.0005365428,0.0004912884,0.00002507258,0.0003860844,0.000168475,0.0002415794,0.0004235646,0.0000815758],"category_scores_gemma":[0.0004134695,0.0005569026,0.000116977,0.0002089246,0.0005489785,0.0001644925,0.0001644916,0.0002791815,0.000004602029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001817782,"about_ca_system_score_gemma":0.0001392307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002079931,"about_ca_topic_score_gemma":0.000002550742,"domain_scores_codex":[0.997609,0.0000134127,0.000560275,0.0009486437,0.0002720973,0.000596572],"domain_scores_gemma":[0.9982182,0.0001382212,0.0003096414,0.0004582657,0.0004240939,0.0004515128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001432997,0.0001594286,0.000803386,0.001631838,0.0002670124,0.000006584663,0.0003828208,0.00004815733,0.989213,0.00006892974,0.005542834,0.001732662],"study_design_scores_gemma":[0.003011371,0.0000394798,0.00001232811,0.0001574993,0.0001831762,0.0001047572,0.002218632,0.003207688,0.9595205,0.0006894355,0.03022673,0.0006284497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895333,0.00633665,0.0002919901,0.0008016789,0.00002071534,0.0003063371,0.0006507134,0.0002136924,0.001844946],"genre_scores_gemma":[0.9934447,0.0008347654,0.0005275112,0.0000645617,0.000351124,0.0003913486,0.001548519,0.00005372136,0.002783743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0296926,"threshold_uncertainty_score":0.9996883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05945795980105454,"score_gpt":0.3128626229184703,"score_spread":0.2534046631174157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}