{"id":"W2225873253","doi":"10.1371/journal.pgen.1005768","title":"Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Ministerio de Ciencia e Innovación; Deutscher Akademischer Austauschdienst; Universitat Pompeu Fabra","keywords":"Biology; Spliceosome; Intron; RNA splicing; Genetics; Splicing factor; Alternative splicing; Splice site mutation; SR protein; Cell biology; Gene; RNA; Exon","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001736733,0.0001840535,0.0001813805,0.00006765523,0.0001302969,0.00001515968,0.0003725334,0.0001159325,0.00002681543],"category_scores_gemma":[0.0002812455,0.0001174287,0.00008663523,0.000157925,0.00008693843,0.000006531928,0.0001313027,0.00008416,0.00004317042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002328336,"about_ca_system_score_gemma":0.00005747199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001192591,"about_ca_topic_score_gemma":0.00003527257,"domain_scores_codex":[0.9985341,0.00008634781,0.000273757,0.0003641727,0.0003180026,0.00042359],"domain_scores_gemma":[0.9987559,0.00007467577,0.0001139674,0.0006588968,0.000219411,0.0001771846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000287441,0.00008479084,0.00727799,0.00003965133,0.00007759674,0.00000162695,0.00006414334,0.00005766123,0.9908096,0.00001541345,0.0002189561,0.001065148],"study_design_scores_gemma":[0.000997319,0.0002610558,0.01479198,0.00006112628,0.0000249479,0.000004620499,0.00008546256,0.0001384845,0.9819782,0.00001593904,0.001468697,0.0001722068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967456,0.0004549097,0.001043221,0.0009135787,0.00003193468,0.0005610119,0.00004499155,0.00001388538,0.0001908816],"genre_scores_gemma":[0.9978008,0.0003426002,0.0002392376,0.0002391596,0.0002669783,0.00005892285,0.000009023399,0.00003627586,0.001006968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008831415,"threshold_uncertainty_score":0.4788604,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141553900609013,"score_gpt":0.2550986906996083,"score_spread":0.240943300638707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}