{"id":"W2225873253","doi":"10.1371/journal.pgen.1005768","title":"Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation","year":2016,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Ministerio de Ciencia e Innovación; Deutscher Akademischer Austauschdienst; Universitat Pompeu Fabra","keywords":"Biology; Spliceosome; Intron; RNA splicing; Genetics; Splicing factor; Alternative splicing; Splice site mutation; SR protein; Cell biology; Gene; RNA; Exon","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002582045,0.0005166109,0.0002798038,0.0002573507,0.0003039933,0.000595306,0.0003115732,0.0003062641,0.001510674],"category_scores_gemma":[0.0002889883,0.0002506542,0.0002625706,0.000144187,0.0003448626,0.0003538417,0.0005389829,0.0005376813,0.001131527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003673412,"about_ca_system_score_gemma":0.0002571846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004088105,"about_ca_topic_score_gemma":0.0007136987,"domain_scores_codex":[0.9997783,0.00004190948,0.00002405557,0.00005684711,0.00005497666,0.00004393098],"domain_scores_gemma":[0.9998099,0.00004525289,0.00004916402,0.00002811832,0.00002876235,0.00003884827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008125288,0.000006848618,0.000365127,0.0000287257,0.000002595105,0.00008621464,0.00001182937,0.00007220725,0.9969574,0.0004126496,0.00003618413,0.001938926],"study_design_scores_gemma":[0.00001148161,0.00004996737,0.004240066,0.000004533783,0.000007195312,0.000376497,0.00002458396,0.001395043,0.9918502,0.0002831657,0.001749826,0.000007419915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835362,0.001957301,0.01055325,0.0001575534,0.00003690843,0.00002211196,0.0002326029,0.0002802761,0.003223693],"genre_scores_gemma":[0.9947175,0.0004502273,0.002860015,0.00003275197,0.00001003243,0.00001290389,0.0002256337,0.00005503765,0.001635834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001510674,"threshold_uncertainty_score":0.005053699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141553900609013,"score_gpt":0.2550986906996083,"score_spread":0.240943300638707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}