{"id":"W2226061200","doi":"10.1371/journal.pone.0143490","title":"Varenicline Effects on Smoking, Cognition, and Psychiatric Symptoms in Schizophrenia: A Double-Blind Randomized Trial","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; H. Lundbeck A/S; National Natural Science Foundation of China; National Institute of Mental Health; Pfizer Pharmaceuticals; Sanofi; Pfizer; National Alliance for Research on Schizophrenia and Depression; Teva Pharmaceutical Industries; Eli Lilly and Company","keywords":"Varenicline; Placebo; Smoking cessation; Schizophrenia (object-oriented programming); Nicotine; Psychiatry; Medicine; Cognition; Effects of sleep deprivation on cognitive performance; Psychology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001701107,0.001213654,0.003302333,0.0005622043,0.0005204295,0.0007328933,0.0009404424,0.002357943,0.007363748],"category_scores_gemma":[0.001562363,0.0006788222,0.00149124,0.0004878494,0.001122373,0.0007338914,0.000341049,0.001463688,0.0008720708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005766068,"about_ca_system_score_gemma":0.001012275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154851,"about_ca_topic_score_gemma":0.002356215,"domain_scores_codex":[0.9992259,0.0004095856,0.00009345018,0.0001266267,0.00005889312,0.00008563327],"domain_scores_gemma":[0.9990392,0.0002996629,0.0002495598,0.00007149314,0.00008118938,0.0002589275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9791423,0.002997025,0.0003763468,0.001504687,0.0008274518,0.0000281223,0.0000245548,0.0001022639,0.001666064,0.00005809546,0.0003835703,0.01288949],"study_design_scores_gemma":[0.9737473,0.02417118,0.001008383,0.00005303388,0.0003434487,0.00001876298,0.00001001859,0.0001544998,0.0001699922,0.00004934691,0.0002656275,0.000008417002],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662066,0.02073946,0.001007603,0.0008567256,0.001064859,0.006380333,0.00147549,0.0002366785,0.002032343],"genre_scores_gemma":[0.9771875,0.008587886,0.002252195,0.001504194,0.0008591948,0.005588436,0.0008267245,0.00002467683,0.003169191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007363748,"threshold_uncertainty_score":0.02463418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01968582297433017,"score_gpt":0.2629578267985983,"score_spread":0.2432720038242681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}