{"id":"W2226252597","doi":"10.1371/journal.pcbi.1004482","title":"K+ Block Is the Mechanism of Functional Asymmetry in Bacterial Nav Channels","year":2016,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Innovates - Health Solutions; Alberta Innovates - Technology Futures; Western Canada Research Grid; Compute Canada; University of Southern California; Alberta Innovates; U.S. Department of Energy","keywords":"Ion; Molecular dynamics; Permeation; Chemistry; Umbrella sampling; Chemical physics; Energy landscape; Ion channel; Potential of mean force; Biophysics; Molecular physics; Computational chemistry; Membrane; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385948,0.00009778442,0.0001104138,0.00007597615,0.00004581988,0.00000469994,0.00009543038,0.0001428101,0.0001869431],"category_scores_gemma":[0.00007707279,0.00006025758,0.00006461491,0.00009393475,0.00009521285,0.00000401943,0.00005929636,0.00004081663,0.00002634604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000144186,"about_ca_system_score_gemma":0.00005869098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003854211,"about_ca_topic_score_gemma":0.000002820267,"domain_scores_codex":[0.999226,0.00009131808,0.000230566,0.0002320553,0.00008703026,0.0001330095],"domain_scores_gemma":[0.9995371,0.00008393539,0.00009734286,0.0001113763,0.0001431253,0.00002719485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008073529,0.0001936352,0.00163847,0.0000119944,0.0001404586,5.776071e-7,0.0000734935,0.00212749,0.9426351,0.04725733,0.002929026,0.002185057],"study_design_scores_gemma":[0.006829354,0.002393349,0.01712859,0.00008690719,0.00004598983,0.00007840832,0.0001310314,0.01629732,0.8043876,0.120461,0.03137397,0.0007864624],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9622524,0.00005419155,0.03334707,0.002625148,0.001181215,0.0001808598,0.0000727275,0.00001071022,0.0002756233],"genre_scores_gemma":[0.9982247,0.00001296864,0.0001982039,0.0004634508,0.0006097035,0.00002020455,0.0001914913,0.000008775423,0.0002704991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1382475,"threshold_uncertainty_score":0.2457233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01890103815111043,"score_gpt":0.2348353679326711,"score_spread":0.2159343297815606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}