{"id":"W2226492912","doi":"10.1093/hmg/ddv632","title":"Conserved pharmacological rescue of hereditary spastic paraplegia-related phenotypes across model organisms","year":2016,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Université de Montréal; Women and Children’s Health Research Institute; University of Alberta","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs","keywords":"Biology; Hereditary spastic paraplegia; Phenotype; Zebrafish; Unfolded protein response; Genetics; Mutation; Gene; Model organism; Loss function","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00016673,0.0006590491,0.0004740425,0.0006629432,0.0002215431,0.0002199102,0.0004595146,0.000433587,0.001594676],"category_scores_gemma":[0.0001379425,0.0001584139,0.0003277521,0.0002153815,0.0003567706,0.0002183168,0.0003262702,0.0008054287,0.0002344486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004215339,"about_ca_system_score_gemma":0.0005040368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001675557,"about_ca_topic_score_gemma":0.005261833,"domain_scores_codex":[0.9998005,0.00003299747,0.00002600019,0.00004590411,0.00005553794,0.00003904859],"domain_scores_gemma":[0.9998382,0.00001644211,0.00005360395,0.00002043861,0.00002379364,0.00004738953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001099631,0.00009244662,0.00007478884,0.00004891645,0.00001034079,0.00005786298,0.00001101519,0.00006910033,0.998269,0.00006680803,0.00004612377,0.001143601],"study_design_scores_gemma":[0.00005897576,0.002143753,0.003383431,0.00002118379,0.00003685013,0.0001981785,0.00003727615,0.0005577837,0.9921454,0.00005523679,0.001353749,0.000008112412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927617,0.001312488,0.002355359,0.000185113,0.00005289277,0.0001316573,0.0009632435,0.0002783814,0.001959177],"genre_scores_gemma":[0.9881307,0.002058549,0.004838105,0.0001088064,0.00001122295,0.0001791493,0.001095181,0.00005978802,0.00351848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001675557,"threshold_uncertainty_score":0.005334675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04912830016099377,"score_gpt":0.3065877260691182,"score_spread":0.2574594259081244,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}