{"id":"W2226515367","doi":"10.1136/annrheumdis-2015-eular.3594","title":"OP0169 Apremilast, an Oral Phosphodiesterase 4 Inhibitor, is Associated with Long-Term (104-Week) Improvements in Enthesitis and Dactylitis in Patients with Psoriatic Arthritis: Pooled Results from Three Phase 3, Randomized, Controlled Trials","year":2015,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Dactylitis; Medicine; Apremilast; Enthesitis; Psoriatic arthritis; Enthesopathy; Internal medicine; Randomized controlled trial; Placebo; Surgery; Dermatology; Arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003293808,0.001140459,0.004618192,0.0005656945,0.000289299,0.0009805603,0.000586873,0.0009789724,0.002717837],"category_scores_gemma":[0.002269065,0.0006057356,0.004025941,0.0007558949,0.000596474,0.0007998309,0.0003575422,0.001868752,0.0003519882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003655285,"about_ca_system_score_gemma":0.0005617804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008011081,"about_ca_topic_score_gemma":0.002366573,"domain_scores_codex":[0.9989908,0.0005126909,0.0001354109,0.0001356386,0.0001375181,0.00008789298],"domain_scores_gemma":[0.9988443,0.0005273022,0.0003661978,0.00005421358,0.00007145799,0.0001366003],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.8190198,0.001679155,0.003181848,0.01657825,0.03787944,0.0001350952,0.00005997484,0.0009947337,0.006560145,0.0001338459,0.001870883,0.1119068],"study_design_scores_gemma":[0.863983,0.06897248,0.02958039,0.0007440373,0.03124208,0.0003570817,0.0000945853,0.001026216,0.00141369,0.0003053878,0.00220815,0.00007285574],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7688681,0.219665,0.001889101,0.001138762,0.001038051,0.001309601,0.001963053,0.000334114,0.003794349],"genre_scores_gemma":[0.9476585,0.04587772,0.001651948,0.001052512,0.0005333566,0.000590109,0.001335528,0.00002445052,0.001275936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004618192,"threshold_uncertainty_score":0.01741958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0313836493141773,"score_gpt":0.2849350386890698,"score_spread":0.2535513893748925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}