{"id":"W2226515367","doi":"10.1136/annrheumdis-2015-eular.3594","title":"OP0169 Apremilast, an Oral Phosphodiesterase 4 Inhibitor, is Associated with Long-Term (104-Week) Improvements in Enthesitis and Dactylitis in Patients with Psoriatic Arthritis: Pooled Results from Three Phase 3, Randomized, Controlled Trials","year":2015,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Dactylitis; Medicine; Apremilast; Enthesitis; Psoriatic arthritis; Enthesopathy; Internal medicine; Randomized controlled trial; Placebo; Surgery; Dermatology; Arthritis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00145834,0.0003149663,0.00160261,0.000092427,0.0000550315,0.00007483594,0.0001638626,0.0001101419,0.00001682022],"category_scores_gemma":[0.003165684,0.0001832479,0.0001997096,0.000134582,0.0001916905,0.00005649725,0.00007610733,0.00007322329,6.576184e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002510214,"about_ca_system_score_gemma":0.0001433198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003280025,"about_ca_topic_score_gemma":0.001071195,"domain_scores_codex":[0.9966824,0.0009901283,0.001223487,0.0004071239,0.0004320467,0.0002648331],"domain_scores_gemma":[0.9977221,0.0004054737,0.001006962,0.0004285761,0.0002492074,0.000187708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7266573,0.006498708,0.2029264,0.00008687117,0.003203243,0.00001659185,0.001384492,0.0002047516,0.0003015669,0.000009006278,0.0007925626,0.0579185],"study_design_scores_gemma":[0.6570958,0.001546993,0.3325239,0.002091484,0.0005061424,8.858898e-7,0.0001355513,0.0006641921,0.004678074,0.0003864526,0.00000329723,0.0003671871],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947946,0.001915976,0.00006499505,0.0001494157,0.0001472541,0.002070912,0.0008300659,0.00001088135,0.00001589949],"genre_scores_gemma":[0.9982826,0.000304591,0.00003479962,0.0002484201,0.0000288527,0.0001628099,0.0008754241,0.00002500739,0.00003746913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1295975,"threshold_uncertainty_score":0.7472631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0313836493141773,"score_gpt":0.2849350386890698,"score_spread":0.2535513893748925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}