{"id":"W2226721679","doi":"10.1038/nature16508","title":"Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":629,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"Congressionally Directed Medical Research Programs; National Human Genome Research Institute; National Cancer Institute; Dana-Farber/Harvard Cancer Center; Ludwig Center at Harvard; National Institutes of Health; Cancer Research UK; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense; Princess Margaret Cancer Foundation; Cancer Prevention and Research Institute of Texas; Susan G. Komen for the Cure","keywords":"Bromodomain; BRD4; Triple-negative breast cancer; BET inhibitor; Chromatin; Cancer research; Breast cancer; Cancer; Epigenetics; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002601584,0.0001094981,0.00009819998,0.00006915217,0.00003584245,0.00001209723,0.00009263098,0.0005192613,0.00002169495],"category_scores_gemma":[0.0003719852,0.00007826955,0.00002738672,0.0001521072,0.00005036192,0.000006875978,0.00006066137,0.0002346411,0.000004093665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004321204,"about_ca_system_score_gemma":0.00006601093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001399198,"about_ca_topic_score_gemma":0.0004694107,"domain_scores_codex":[0.9991778,0.0001227652,0.0001229978,0.0003018829,0.0001122125,0.0001623416],"domain_scores_gemma":[0.9996105,0.00003001461,0.00003992507,0.0001746768,0.00005934581,0.0000855174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002614933,0.00002099243,0.003733055,0.000006223073,0.00001064824,0.00000495662,0.00007034093,2.92083e-7,0.9362544,0.0001541806,0.05315011,0.00397991],"study_design_scores_gemma":[0.001760917,0.00009564424,0.1021135,0.0001773893,0.000003352951,0.000007656637,0.00004347708,4.091147e-7,0.7637443,0.0004245154,0.1313813,0.0002475456],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981438,0.001174191,0.00005468983,0.01645111,0.0001728795,0.0002530364,0.0001909504,0.000009415957,0.0002557312],"genre_scores_gemma":[0.9944171,0.0001080801,0.0004028439,0.001493588,0.0001586621,0.00004357413,0.000005860951,0.00001322753,0.00335711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1725101,"threshold_uncertainty_score":0.4005019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003928327806201479,"score_gpt":0.251001048709911,"score_spread":0.2470727209037095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}