{"id":"W2226721679","doi":"10.1038/nature16508","title":"Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer","year":2016,"lang":"en","type":"article","venue":"Nature","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":629,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; University of Toronto","funders":"Congressionally Directed Medical Research Programs; National Human Genome Research Institute; National Cancer Institute; Dana-Farber/Harvard Cancer Center; Ludwig Center at Harvard; National Institutes of Health; Cancer Research UK; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Defense; Princess Margaret Cancer Foundation; Cancer Prevention and Research Institute of Texas; Susan G. Komen for the Cure","keywords":"Bromodomain; BRD4; Triple-negative breast cancer; BET inhibitor; Chromatin; Cancer research; Breast cancer; Cancer; Epigenetics; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002722878,0.0001272622,0.0003331034,0.0002509914,0.0001457594,0.000350298,0.0001291666,0.0003017543,0.001953019],"category_scores_gemma":[0.000306044,0.00011746,0.000166614,0.0001647453,0.0001306426,0.0001472459,0.0001263393,0.0004834385,0.0002612969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004427795,"about_ca_system_score_gemma":0.000141983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004203221,"about_ca_topic_score_gemma":0.0007553555,"domain_scores_codex":[0.9998652,0.00002091717,0.00001017531,0.00001592008,0.00004510016,0.00004284029],"domain_scores_gemma":[0.9998584,0.00004013055,0.00003025919,0.00001607527,0.00001561557,0.00003954868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003616589,0.000284559,0.008319691,0.00008302522,0.00005344677,0.0005838376,0.0000679453,0.0006941646,0.9553868,0.0006720487,0.00142644,0.02881148],"study_design_scores_gemma":[0.0004160143,0.006978415,0.1691556,0.00003313977,0.0001811966,0.01112729,0.000385365,0.005999965,0.7747443,0.001361711,0.02958088,0.00003622654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925261,0.003936279,0.0003135217,0.0003348622,0.0000343662,0.00001391757,0.0002150706,0.00003788496,0.002588035],"genre_scores_gemma":[0.9971124,0.0008261398,0.000122512,0.00008186548,0.000008422225,0.00001151209,0.000217771,0.00000555116,0.001613714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001953019,"threshold_uncertainty_score":0.006533444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003928327806201479,"score_gpt":0.251001048709911,"score_spread":0.2470727209037095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}