{"id":"W2226995406","doi":"10.1002/jbt.21784","title":"The Effects of the Organic Flame‐Retardant 1,2‐Dibromo‐4‐(1,2‐dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines","year":2016,"lang":"en","type":"article","venue":"Journal of Biochemical and Molecular Toxicology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada; Vancouver Coastal Health Research Institute; Vancouver Coastal Health; Simon Fraser University","funders":"","keywords":"LNCaP; Androgen receptor; Prostate cancer; Chemistry; Fire retardant; Androgen; Endocrinology; Internal medicine; Cancer research; Receptor; Prostate; Signal transduction; Cancer; Biology; Hormone; Medicine; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001173184,0.0002782834,0.0001726245,0.0002420269,0.0001753651,0.0002169082,0.00009302716,0.0001299271,0.001175681],"category_scores_gemma":[0.00008198669,0.0001328421,0.0001972965,0.0002895758,0.000146533,0.00009084267,0.00009281212,0.0002095068,0.0002501567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001992247,"about_ca_system_score_gemma":0.0003013955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004532625,"about_ca_topic_score_gemma":0.008206123,"domain_scores_codex":[0.9998562,0.00003286693,0.00001352536,0.00001807934,0.00004668192,0.00003266098],"domain_scores_gemma":[0.999938,0.00001753822,0.000009103959,0.000007038203,0.00001711612,0.00001113162],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002153018,0.00003205258,0.000435109,0.00004181321,0.000007895918,0.00004062206,0.00002136881,0.00007966348,0.9981469,0.00002450764,0.00003124317,0.0009235984],"study_design_scores_gemma":[0.000006777283,0.0004216727,0.003862514,0.000002510397,0.00001380345,0.00007102042,0.00004499062,0.0001174508,0.9946107,0.000008728902,0.0008371104,0.000002922402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943103,0.002428674,0.0009146676,0.00006094057,0.00002802228,0.00002814961,0.0005817533,0.00002657291,0.001620853],"genre_scores_gemma":[0.9917508,0.002776579,0.00140881,0.00005251729,0.00001010115,0.00003412376,0.0008139566,0.000008060948,0.003145195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004532625,"threshold_uncertainty_score":0.00901252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003159237301332669,"score_gpt":0.2140476028274997,"score_spread":0.210888365526167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}