{"id":"W2226995406","doi":"10.1002/jbt.21784","title":"The Effects of the Organic Flame‐Retardant 1,2‐Dibromo‐4‐(1,2‐dibromoethyl) Cyclohexane (TBECH) on Androgen Signaling in Human Prostate Cancer Cell Lines","year":2016,"lang":"en","type":"article","venue":"Journal of Biochemical and Molecular Toxicology","topic":"Toxic Organic Pollutants Impact","field":"Environmental Science","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada; Vancouver Coastal Health Research Institute; Vancouver Coastal Health; Simon Fraser University","funders":"","keywords":"LNCaP; Androgen receptor; Prostate cancer; Chemistry; Fire retardant; Androgen; Endocrinology; Internal medicine; Cancer research; Receptor; Prostate; Signal transduction; Cancer; Biology; Hormone; Medicine; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000330675,0.0001703669,0.0002773874,0.00002700769,0.0000803871,0.00001233746,0.0003965162,0.0001368103,0.0001463231],"category_scores_gemma":[0.0002875622,0.00007746604,0.0001047226,0.0001591435,0.0004278887,0.00005792824,0.000167173,0.0002328595,0.000002315968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001891163,"about_ca_system_score_gemma":0.00004749306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002123545,"about_ca_topic_score_gemma":0.00004021695,"domain_scores_codex":[0.9985519,0.0001814434,0.000447546,0.0001950816,0.00029174,0.0003322624],"domain_scores_gemma":[0.9990296,0.0002480036,0.000369008,0.0002156599,0.000007741209,0.0001300317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007720043,0.0001010919,0.001101154,0.00001302002,0.00002805681,0.00004832464,0.0001318428,0.000003397837,0.9924481,0.000004682846,0.0001129637,0.005930166],"study_design_scores_gemma":[0.001032355,0.0005442976,0.006879627,0.0001349282,0.00003795047,0.00008312165,0.00002088218,0.000002815616,0.9903263,0.0005321736,0.0002948549,0.000110629],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963356,0.001488261,0.00001185348,0.00171935,0.0001723059,0.0001979655,0.000009306896,0.000004223808,0.00006110052],"genre_scores_gemma":[0.9990454,0.0004897512,0.00004242872,0.000271994,0.00004091852,0.000002833822,8.122535e-8,0.00001863732,0.00008793645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005819537,"threshold_uncertainty_score":0.3158973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003159237301332669,"score_gpt":0.2140476028274997,"score_spread":0.210888365526167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}