{"id":"W2228653004","doi":"10.1038/srep18537","title":"Overexpression of HER-2 in MDA-MB-435/LCC6 Tumours is Associated with Higher Metabolic Activity and Lower Energy Stress","year":2016,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia Hospital; University of British Columbia; University Health Network; TRIUMF; BC Cancer Agency","funders":"Canadian Institutes of Health Research; Cancer Research Society; Breast Cancer Alliance","keywords":"GLUT1; Hypoxia (environmental); Glucose transporter; Glucose uptake; Perfusion; Carbohydrate metabolism; Glucose Transporter Type 1; Positron emission tomography; In vitro; Necrosis; Metabolism; Biology; Chemistry; Medicine; Pathology; Endocrinology; Internal medicine; Oxygen; Nuclear medicine; Biochemistry; Insulin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001780793,0.000308304,0.0004246894,0.0003311324,0.0002108364,0.0003984107,0.0001354625,0.0003510287,0.00212991],"category_scores_gemma":[0.0001297237,0.0001946824,0.0003168013,0.0003939521,0.0001969807,0.0002396215,0.0001693332,0.0008273157,0.0004354381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004363281,"about_ca_system_score_gemma":0.00023707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003562499,"about_ca_topic_score_gemma":0.003311153,"domain_scores_codex":[0.999718,0.00002251424,0.00001933041,0.0000482734,0.0001243142,0.00006753123],"domain_scores_gemma":[0.9998364,0.00001528644,0.00004423902,0.00001340443,0.00002507811,0.00006558237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001169344,0.00003271782,0.0003161929,0.00002188095,0.000005764606,0.00003085417,0.00001575005,0.00002929139,0.998908,0.00003178953,0.00006103039,0.0004298536],"study_design_scores_gemma":[0.00001991082,0.000705265,0.02793176,0.000005766903,0.00003217091,0.000610978,0.00008488735,0.001175766,0.9665307,0.00004153097,0.00285235,0.000008874963],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959803,0.0008655048,0.0009900909,0.0001158158,0.00003226137,0.00001561418,0.0009444208,0.00008668347,0.0009693047],"genre_scores_gemma":[0.9914157,0.000651288,0.001657414,0.00007724135,0.00001064031,0.0000455976,0.001617762,0.000032491,0.004491925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003562499,"threshold_uncertainty_score":0.007125258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006939749645221959,"score_gpt":0.2256522880754563,"score_spread":0.2187125384302344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}