{"id":"W2229145282","doi":"10.1074/jbc.m115.679993","title":"Validation and Characterization of a Novel Peptide That Binds Monomeric and Aggregated β-Amyloid and Inhibits the Formation of Neurotoxic Oligomers","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Medical Research Council; University of Toronto; National Health and Medical Research Council; Edith Cowan University; Curtin University of Technology","keywords":"Peptide; Amyloid (mycology); Monomer; Chemistry; Characterization (materials science); Biochemistry; P3 peptide; Amyloid precursor protein; Biophysics; Biology; Medicine; Alzheimer's disease; Internal medicine; Nanotechnology; Materials science; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005261209,0.0003377465,0.0004624596,0.0001759562,0.000177757,0.0004908632,0.0003843322,0.0005002605,0.0006497341],"category_scores_gemma":[0.0004785235,0.0001404353,0.0003559629,0.0002259782,0.0002468645,0.0002313105,0.0002008201,0.0005203166,0.0004031027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002403194,"about_ca_system_score_gemma":0.0003500633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004529179,"about_ca_topic_score_gemma":0.000322363,"domain_scores_codex":[0.9997571,0.00004664143,0.00002631803,0.00004687134,0.00008570445,0.00003731115],"domain_scores_gemma":[0.9997196,0.00005379223,0.000048239,0.00002906548,0.00007820142,0.00007111138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006175592,0.00009073455,0.0001570238,0.00003269046,0.000006732509,0.0000436614,0.00001551644,0.0001773864,0.9981165,0.0000428845,0.00001798019,0.001237105],"study_design_scores_gemma":[0.00008292907,0.002862952,0.003156506,0.00001217291,0.00003908906,0.0008149256,0.00002659,0.002573458,0.9860119,0.00005075229,0.004356979,0.00001157172],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908702,0.0009888492,0.007022459,0.00006498433,0.00002660367,0.0001532849,0.0002797948,0.00002475949,0.0005690739],"genre_scores_gemma":[0.9799642,0.0008734915,0.01590696,0.0001369982,0.00002522451,0.00009596744,0.001572327,0.00002710627,0.00139777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006497341,"threshold_uncertainty_score":0.002782404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06826234168640077,"score_gpt":0.292942832000663,"score_spread":0.2246804903142622,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}