{"id":"W2229338424","doi":"10.1161/atvb.33.suppl_1.a10","title":"Abstract 10: Randomized, Double-Blind, Placebo-Controlled Single Ascending Dose Pharmacokinetic and Pharmacodynamic Study of PRT064445, a Universal Antidote for Factor Xa Inhibitors","year":2013,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Antidote; Rivaroxaban; Medicine; Cmax; Pharmacology; Pharmacokinetics; Placebo; Pharmacodynamics; Prothrombin complex concentrate; Anesthesia; Warfarin; Internal medicine; Toxicity; Atrial fibrillation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002474742,0.002148492,0.005203174,0.0006254373,0.0006834688,0.001692228,0.001211131,0.00303441,0.01311386],"category_scores_gemma":[0.00206278,0.001292292,0.001388426,0.000487034,0.002070229,0.001867292,0.0004742935,0.004138002,0.003376611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007393925,"about_ca_system_score_gemma":0.002653062,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005924244,"about_ca_topic_score_gemma":0.001060427,"domain_scores_codex":[0.9988342,0.0004297273,0.0001145518,0.0003130701,0.00009963585,0.0002088179],"domain_scores_gemma":[0.9986689,0.0002299058,0.00023081,0.0001491453,0.0001466002,0.0005746963],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9716104,0.01460137,0.0001516585,0.0004146241,0.0002670138,0.00002475835,0.00002633275,0.0001125899,0.005756704,0.00007976736,0.0007011747,0.006253699],"study_design_scores_gemma":[0.8995742,0.09821358,0.0006045202,0.00001817705,0.0001257791,0.00001889997,0.000007222418,0.000248542,0.0005454408,0.00007064359,0.0005602242,0.00001277887],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9478198,0.00414846,0.003212781,0.001361381,0.002304478,0.03243619,0.003543666,0.0008951155,0.004278047],"genre_scores_gemma":[0.9334578,0.004060697,0.007733704,0.003576927,0.001807939,0.03273812,0.003298261,0.0001454581,0.01318109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01311386,"threshold_uncertainty_score":0.04387021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05956697690600767,"score_gpt":0.3230501032877326,"score_spread":0.2634831263817249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}