{"id":"W2229879192","doi":"10.1155/2015/921712","title":"A new Era of Personalized Medicine for Cystic Fibrosis – at Last!","year":2015,"lang":"en","type":"review","venue":"Canadian Respiratory Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"University of British Columbia; Cystic Fibrosis Canada","keywords":"Cystic fibrosis; Medicine; Personalized medicine; Cystic fibrosis transmembrane conductance regulator; Drug discovery; Mutation; Function (biology); Computational biology; Bioinformatics; Drug development; Drug; Gene; Pharmacology; Internal medicine; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00154236,0.0005782009,0.003257142,0.001125072,0.0002379059,0.00004182465,0.0005147748,0.0004197565,0.002231304],"category_scores_gemma":[0.003712099,0.0004279818,0.0008297677,0.0006458962,0.0003922286,0.0001025592,0.00005735201,0.001275936,0.00008160641],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003723196,"about_ca_system_score_gemma":0.02923757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002032107,"about_ca_topic_score_gemma":0.01271619,"domain_scores_codex":[0.9957663,0.0002931783,0.001381094,0.0004805189,0.001089955,0.0009889642],"domain_scores_gemma":[0.9918765,0.0006924651,0.0008049477,0.0005818471,0.0009398483,0.00510434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002163577,0.00001045378,0.00001662958,0.01026976,0.000340232,0.0002840655,0.0000867169,5.778059e-7,0.00002802672,0.00006819446,0.275534,0.713145],"study_design_scores_gemma":[0.002705046,0.001535631,0.00001493978,0.03205321,0.001386863,0.001740567,0.00005014655,0.000002157055,0.000002554444,0.0001093906,0.9600882,0.0003113155],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000124595,0.9960926,0.000312145,0.0003585784,0.0005329886,0.001494759,0.0004533258,0.00001597038,0.0007271357],"genre_scores_gemma":[0.000002614503,0.9871477,0.004702432,0.0004580724,0.002845877,0.00008449973,0.0001334289,0.0001786447,0.004446701],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7128337,"threshold_uncertainty_score":0.9998172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08658891274568124,"score_gpt":0.3850659009953394,"score_spread":0.2984769882496581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}