{"id":"W2229939127","doi":"10.1074/jbc.m115.685883","title":"Mutations in Replicative Stress Response Pathways Are Associated with S Phase-specific Defects in Nucleotide Excision Repair","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Nucleotide excision repair; DNA damage; Biology; DNA repair; DNA replication; Proliferating cell nuclear antigen; Replication protein A; Cell biology; DNA polymerase; Saccharomyces cerevisiae; DNA; S phase; Molecular biology; Genetics; Eukaryotic DNA replication; Gene; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000103864,0.0008131872,0.0002742263,0.0006242507,0.0001396596,0.0001897511,0.0002316396,0.0004733708,0.001822762],"category_scores_gemma":[0.0001685208,0.0001905074,0.0002707761,0.0003056638,0.0002678621,0.0001368761,0.0003267098,0.00039278,0.0006066346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001355063,"about_ca_system_score_gemma":0.0001443205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002791188,"about_ca_topic_score_gemma":0.0003417168,"domain_scores_codex":[0.9998637,0.00001956983,0.00002382002,0.00004310583,0.00003316902,0.00001663938],"domain_scores_gemma":[0.9996413,0.00003626805,0.0001916062,0.00003852821,0.00002245614,0.00006987503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001120336,0.00003266876,0.001997801,0.00003859421,0.00001579696,0.0004183919,0.00001872691,0.00009591009,0.9951944,0.0001178531,0.0000508663,0.001907017],"study_design_scores_gemma":[0.00004110144,0.0009048796,0.1008997,0.00003221109,0.00007952342,0.01030884,0.00008133438,0.001617193,0.8782109,0.0003319691,0.007466471,0.00002575106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921067,0.0015896,0.003862392,0.00006830434,0.00003007187,0.00005115613,0.0008983499,0.000423898,0.0009695787],"genre_scores_gemma":[0.9958402,0.0008212245,0.001430732,0.00003496214,0.00001210711,0.0000270064,0.0007208749,0.00004289096,0.001070132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001822762,"threshold_uncertainty_score":0.006097794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0430400633516265,"score_gpt":0.2807809350455496,"score_spread":0.2377408716939231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}