{"id":"W2230518119","doi":"10.2147/copd.s89849","title":"Roflumilast: a review of its use in the treatment of COPD","year":2016,"lang":"en","type":"article","venue":"International Journal of COPD","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":166,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute for Health and Care Research; McGill University; Takeda Pharmaceuticals International; Takeda Pharmaceuticals North America","keywords":"COPD; Roflumilast; Chronic bronchitis; Placebo; Systemic inflammation; Bronchitis; Exacerbation; Diabetes mellitus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001485651,0.00004999342,0.0001077264,0.00004247663,0.000005242995,0.000004372472,0.0001315997,0.00002794482,0.00005044826],"category_scores_gemma":[0.0001134188,0.00002501737,0.0001041332,0.00003174657,0.00002820007,0.000009630143,0.00000933472,0.00001667109,0.000001670886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002343841,"about_ca_system_score_gemma":0.00005544278,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004440383,"about_ca_topic_score_gemma":0.00001002441,"domain_scores_codex":[0.9993419,0.00005198785,0.0003189291,0.00004909106,0.0001973674,0.00004073924],"domain_scores_gemma":[0.9991618,0.00003763102,0.0002924536,0.00007891312,0.0004133709,0.0000158447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001373231,0.001195148,0.02733068,0.000216854,0.0006047877,0.00004161843,0.000329601,0.00006219577,0.8861822,0.000845903,0.02194347,0.05987432],"study_design_scores_gemma":[0.002606992,0.001155773,0.04234411,0.002728587,0.00004380377,0.0001720539,0.00002933828,0.000008162888,0.3977875,0.0000627022,0.5529726,0.00008839134],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823065,0.01442148,0.0004716172,0.002007969,0.0004586124,0.00009832319,0.00002466944,6.480071e-7,0.0002101283],"genre_scores_gemma":[0.9594346,0.03967477,0.00006204672,0.0003266745,0.0001274327,0.000002112704,0.0000067198,0.000003190262,0.0003624413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5310291,"threshold_uncertainty_score":0.1020179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02049438483015831,"score_gpt":0.2949281682299372,"score_spread":0.2744337833997789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}