{"id":"W2230529021","doi":"10.1371/journal.pone.0144764","title":"Stability of the Plasmodium falciparum AMA1-RON2 Complex Is Governed by the Domain II (DII) Loop","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Malaria Research and Control","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research; Centre National de la Recherche Scientifique; Consejo Nacional de Ciencia y Tecnología; Institut National de la Santé et de la Recherche Médicale; Agence Nationale de la Recherche","keywords":"Isothermal titration calorimetry; Biophysics; Plasmodium falciparum; Chemistry; Receptor–ligand kinetics; Plasma protein binding; Biology; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005193515,0.0001388728,0.0003565273,0.00003218639,0.0001622239,0.00001159047,0.0003954201,0.00007423593,0.003120327],"category_scores_gemma":[0.0005228188,0.00005872764,0.0001267872,0.0002347854,0.0003729564,0.00004925506,0.0002280597,0.0002130312,0.00007477813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009034518,"about_ca_system_score_gemma":0.0001325032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002290157,"about_ca_topic_score_gemma":0.0001017857,"domain_scores_codex":[0.9978861,0.0001933179,0.0002807318,0.0002503701,0.0009807292,0.0004087208],"domain_scores_gemma":[0.9983281,0.0003143256,0.0001081047,0.0009304017,0.00016505,0.0001540079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001229808,0.002069411,0.01446279,0.0001202668,0.0004862411,0.000001993765,0.0003165238,2.066175e-8,0.95197,0.001571558,0.02693591,0.0008354115],"study_design_scores_gemma":[0.01203679,0.001407926,0.1284351,0.0003937309,0.0004099668,0.000005173433,0.0004059591,0.0003635852,0.8276461,0.001938473,0.02667702,0.0002802116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8678719,0.0001660495,0.00006179434,0.1244265,0.00002128606,0.000945114,0.0003305489,0.0000253595,0.00615148],"genre_scores_gemma":[0.9916749,0.00005216876,0.00009609394,0.0009881421,0.00008421433,0.0000666356,0.000006076029,0.00001658909,0.007015171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.124324,"threshold_uncertainty_score":0.9977909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05890618367613082,"score_gpt":0.2612646849377118,"score_spread":0.2023585012615809,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}