{"id":"W2231133613","doi":"10.1097/00008571-200301000-00006","title":"Role of CYP2D6 in the stereoselective disposition of venlafaxine in humans.","year":2003,"lang":"en","type":"article","venue":"Pharmacogenetics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Université de Montréal","funders":"","keywords":"Quinidine; Venlafaxine; CYP2D6; Venlafaxine Hydrochloride; Pharmacology; Pharmacokinetics; Chemistry; Oral administration; Dosing; Internal medicine; Medicine; Metabolism; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004078998,0.0002314464,0.0003162008,0.0003401983,0.0001633362,0.0003178562,0.00009591875,0.0002341803,0.001157112],"category_scores_gemma":[0.0005367062,0.0001387839,0.0002207494,0.0002812773,0.0001906573,0.0001219327,0.000107206,0.0001971254,0.0002218934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001845238,"about_ca_system_score_gemma":0.0001060043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008168171,"about_ca_topic_score_gemma":0.0007787636,"domain_scores_codex":[0.999699,0.0001307863,0.00001708662,0.0000736377,0.00006219317,0.00001732512],"domain_scores_gemma":[0.9997427,0.00005960104,0.0001177989,0.00002616639,0.00002947454,0.00002437434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.006650068,0.0001609023,0.7041895,0.000323213,0.0006988948,0.001776399,0.0002401219,0.0006633751,0.20029,0.0004599232,0.0006918034,0.08385587],"study_design_scores_gemma":[0.00007602544,0.001143411,0.9568213,0.00001694888,0.0001845399,0.006017274,0.00007850625,0.0009561789,0.02944538,0.0002475956,0.005001899,0.00001106526],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823838,0.01212123,0.002781022,0.0002177565,0.00002624509,0.00002415707,0.0005409215,0.0000317351,0.001873191],"genre_scores_gemma":[0.9971086,0.001149868,0.0007887048,0.00005649637,0.00002654698,0.000006157021,0.0002664624,0.000007001281,0.0005901185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157112,"threshold_uncertainty_score":0.003870904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0721968665002955,"score_gpt":0.4240910537009301,"score_spread":0.3518941872006346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}