{"id":"W2231145543","doi":"10.1103/physreve.92.062712","title":"Role of DNA binding sites and slow unbinding kinetics in titration-based oscillators","year":2015,"lang":"en","type":"article","venue":"Physical Review E","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Canadian Aeronautics and Space Institute","keywords":"Repressor; DNA; Cooperativity; Biophysics; Cooperative binding; Physics; Noise (video); Binding site; Biology; Chemistry; Genetics; Gene; Computer science; Transcription factor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007745613,0.0005051464,0.0006367436,0.000383948,0.0003625624,0.0008691335,0.0007663644,0.0008762246,0.0009040922],"category_scores_gemma":[0.003849713,0.0004850673,0.0004980161,0.0002050978,0.001301875,0.001016771,0.0008503748,0.0009279833,0.0001635205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005659838,"about_ca_system_score_gemma":0.0004334743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005660766,"about_ca_topic_score_gemma":0.0003523388,"domain_scores_codex":[0.9997023,0.0001159098,0.00001622416,0.00006538298,0.0000717943,0.00002845566],"domain_scores_gemma":[0.998481,0.001006567,0.0002144699,0.0001018947,0.00006221617,0.0001337785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002935682,0.0001418084,0.003248437,0.0002505717,0.00007019436,0.0005414336,0.0003759126,0.5286048,0.2648712,0.1855746,0.0003024332,0.01572515],"study_design_scores_gemma":[0.00004888486,0.00009050877,0.001086364,0.00001438243,0.00002408106,0.00009772604,0.00002417123,0.9559014,0.009862683,0.03174823,0.001065767,0.00003558837],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.634042,0.001485232,0.356322,0.0006696427,0.00009313957,0.00004951216,0.00005011161,0.0002153559,0.007073073],"genre_scores_gemma":[0.9834013,0.0005703897,0.01460739,0.00006366468,0.00002361779,0.00005875909,0.00001645421,0.00004147009,0.00121693],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009040922,"threshold_uncertainty_score":0.004106581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01546794599624684,"score_gpt":0.2742376606306005,"score_spread":0.2587697146343536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}