{"id":"W2231200204","doi":"10.1182/blood.v124.21.3460.3460","title":"Interpretation and Application of the International Myeloma Working Group (IMWG) Criteria: Proposal for Uniform Assessment and Reporting in Clinical Trials Based on the First Study Independent Response Adjudication Committee (IRAC) Experience","year":2014,"lang":"en","type":"article","venue":"Blood","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"","keywords":"Medicine; Clinical trial; Discontinuation; Clinical endpoint; Multiple myeloma; Surrogate endpoint; Family medicine; Internal medicine; Oncology; Medical physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.8959286,0.006321627,0.01384018,0.02303673,0.009165122,0.03511941,0.02541881,0.02813599,0.001617169],"category_scores_gemma":[0.8345207,0.008062629,0.01898993,0.01814572,0.02016207,0.0151002,0.0177294,0.04691365,0.003666481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01606938,"about_ca_system_score_gemma":0.06893129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003320979,"about_ca_topic_score_gemma":0.003049721,"domain_scores_codex":[0.06875637,0.6583301,0.1989696,0.01178442,0.05750107,0.004658437],"domain_scores_gemma":[0.06758428,0.4209706,0.1540058,0.1438678,0.2036895,0.009882022],"domain_codex":"methods","domain_gemma":"reporting","domain_candidate":"reporting","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.004755551,0.001182799,0.02325207,0.02301718,0.005947549,0.002122747,0.02401088,0.01804714,0.006070282,0.187799,0.3011947,0.4026001],"study_design_scores_gemma":[0.007809978,0.003525541,0.02741187,0.05524233,0.004167737,0.002661892,0.002792121,0.0591089,0.01601615,0.1841946,0.6345134,0.002555595],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.007212117,0.009930337,0.7666161,0.05387028,0.01312198,0.1302622,0.001502543,0.002291286,0.01519324],"genre_scores_gemma":[0.02483245,0.001503866,0.8856194,0.01468351,0.002984782,0.06802936,0.000839125,0.0005656618,0.0009418902],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.1040714,"threshold_uncertainty_score":0.1283387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1068028260891745,"score_gpt":0.4516710900495154,"score_spread":0.344868263960341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}