{"id":"W2231512968","doi":"10.1136/bjophthalmol-2015-307213","title":"CFH Y402H polymorphism and the complement activation product C5a: effects on NF-κB activation and inflammasome gene regulation","year":2016,"lang":"en","type":"article","venue":"British Journal of Ophthalmology","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of British Columbia","keywords":"Inflammasome; Factor H; Complement system; Proinflammatory cytokine; Tumor necrosis factor alpha; Immunology; Complement factor B; Interleukin; Caspase 1; Alternative complement pathway; Inflammation; Complement factor I; Cytokine; Medicine; Molecular biology; Biology; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002454025,0.0004925026,0.0002892833,0.0003272435,0.0002331945,0.0002169361,0.0001624934,0.0006838799,0.002701481],"category_scores_gemma":[0.000316506,0.0001357598,0.0003567631,0.0002575051,0.0002927079,0.0001091554,0.0001758965,0.0002771137,0.0001419006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002941974,"about_ca_system_score_gemma":0.0001710122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002190594,"about_ca_topic_score_gemma":0.001324771,"domain_scores_codex":[0.9998643,0.0000270739,0.00001185685,0.0000481631,0.00002124538,0.00002738389],"domain_scores_gemma":[0.9997568,0.00006619397,0.00008812427,0.00001744652,0.0000196836,0.00005185679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01458083,0.000304627,0.1376953,0.0001717885,0.0003020829,0.003596736,0.0003567552,0.0002216352,0.8358083,0.0002049136,0.0002131016,0.006543834],"study_design_scores_gemma":[0.0002655435,0.001683114,0.913407,0.00004026039,0.0004851814,0.009290632,0.0001855059,0.0009879669,0.07207135,0.0003912118,0.001165863,0.00002645445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987649,0.0007051125,0.0002176256,0.00003979504,0.000004877327,0.000004916321,0.0001195455,0.000004056338,0.0001391868],"genre_scores_gemma":[0.9992663,0.0001322258,0.0002127963,0.00002190082,0.000008234015,0.00000627061,0.00009917177,0.000003897526,0.0002492013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002701481,"threshold_uncertainty_score":0.009037375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01503716479315531,"score_gpt":0.2700066127184615,"score_spread":0.2549694479253062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}