{"id":"W2231654384","doi":"10.1152/ajpheart.00659.2015","title":"Oxidative stress contributes to the enhanced expression of Gqα/PLCβ1 proteins and hypertrophy of VSMC from SHR: role of growth factor receptor transactivation","year":2016,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Vascular smooth muscle; Oxidative stress; Internal medicine; Endocrinology; Growth factor; Epidermal growth factor receptor; Chemistry; Growth factor receptor; Receptor; Cell biology; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002067913,0.0005670265,0.0004534443,0.0004851521,0.0002183792,0.0002223106,0.0001146807,0.0002277439,0.001292535],"category_scores_gemma":[0.00009542255,0.0002468671,0.0005152151,0.0002146885,0.0002976776,0.0002784957,0.0002578517,0.0007440282,0.0002018985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001858426,"about_ca_system_score_gemma":0.0001306724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001264817,"about_ca_topic_score_gemma":0.001650876,"domain_scores_codex":[0.9998713,0.0000183931,0.00001215292,0.00002890855,0.00003278068,0.0000365076],"domain_scores_gemma":[0.9998648,0.00001210124,0.00004241395,0.00001536963,0.00001842982,0.00004673533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001379177,0.00001825155,0.0003481534,0.00002618738,0.000006452855,0.00004827716,0.00002342104,0.000006128546,0.998863,0.00001637205,0.0000107699,0.0004951425],"study_design_scores_gemma":[0.00007135632,0.001098223,0.1306565,0.00001346478,0.0001006151,0.0007507292,0.0002013816,0.0008484718,0.8644812,0.0001298559,0.001633595,0.00001477206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965713,0.001389058,0.001224777,0.000140874,0.00002727294,0.00001985319,0.0001781811,0.00003657883,0.0004121433],"genre_scores_gemma":[0.994751,0.001612506,0.001350797,0.0001221452,0.00006426975,0.00004127292,0.0004427911,0.00001611571,0.001599041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001292535,"threshold_uncertainty_score":0.004323959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006824685289288202,"score_gpt":0.2262548373715624,"score_spread":0.2194301520822741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}