{"id":"W2231659008","doi":"10.1016/j.celrep.2015.12.060","title":"Conditional Epistatic Interaction Maps Reveal Global Functional Rewiring of Genome Integrity Pathways in Escherichia coli","year":2016,"lang":"en","type":"article","venue":"Cell Reports","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Hospital for Sick Children; Carleton University; University of Toronto; University of Regina","funders":"Canadian Institutes of Health Research","keywords":"Biology; Escherichia coli; Genetics; Computational biology; Genome; Gene; DNA; DNA damage; Epistasis; SOS response","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001987394,0.0003996653,0.0002382878,0.0008962734,0.0001770192,0.0002698805,0.0002805968,0.000245892,0.0009647562],"category_scores_gemma":[0.0003780525,0.0002366885,0.0002464094,0.0003954868,0.000338211,0.0001274298,0.0005472949,0.0004511655,0.0001485556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003522013,"about_ca_system_score_gemma":0.000229725,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001052156,"about_ca_topic_score_gemma":0.002252309,"domain_scores_codex":[0.9997184,0.00005573702,0.00002334486,0.00007062476,0.00007681724,0.00005496811],"domain_scores_gemma":[0.999651,0.0001107927,0.0001120797,0.00004266877,0.00002311471,0.00006031906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009209432,0.0000164685,0.000636602,0.00001611192,0.00001037468,0.00009326311,0.00001394061,0.0002639313,0.9971685,0.0001896844,0.00001921706,0.001479823],"study_design_scores_gemma":[0.00004201206,0.0004678944,0.1049762,0.000008705354,0.0001093157,0.001547452,0.0001851212,0.01505273,0.8740649,0.0008478342,0.002650474,0.00004739386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905634,0.0001490065,0.007926845,0.00005102884,0.000004915215,0.00002002773,0.0004220393,0.0001548992,0.0007078422],"genre_scores_gemma":[0.9957782,0.000105223,0.003257142,0.00003418309,0.000001942569,0.00001722294,0.0003051108,0.00003941931,0.0004615649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001052156,"threshold_uncertainty_score":0.003227472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01340472495516249,"score_gpt":0.2387643458259806,"score_spread":0.2253596208708181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}